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MAPK3 Knockout Cell Lines

Gene: MAPK3

Official Full Name: mitogen-activated protein kinase 3provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO11526 MAPK3 Knockout cell line (HeLa) Human MAPK3 1:3~1:6 Negative Online Inquiry
KO11527 MAPK3 Knockout cell line (HCT 116) Human MAPK3 1:2~1:4 Negative Online Inquiry
KO11528 MAPK3 Knockout cell line (HEK293) Human MAPK3 1:3~1:6 Negative Online Inquiry
KO11529 MAPK3 Knockout cell line (A549) Human MAPK3 1:3~1:4 Negative Online Inquiry

Background

MAPK3 Gene Knockout Cell Lines are a specialized tool for researchers aiming to study the biological roles of the MAPK3 (Mitogen-Activated Protein Kinase 3) gene, which plays a critical role in various cellular processes, including proliferation, differentiation, and response to stress. These cell lines are engineered to have a complete knockout of the MAPK3 gene, enabling researchers to analyze the downstream effects of loss of MAPK3 function in a controlled environment.

The primary mechanism of action for these knockout cell lines involves the disruption of MAPK3 signaling pathways, which can alter cellular response to growth factors, hormones, and environmental signals. By utilizing these cell lines, scientists can investigate how the absence of MAPK3 affects critical processes such as apoptosis and cell cycle progression, thereby providing insights into its contributions to diseases, including cancer and neurodegenerative disorders. The findings derived from using MAPK3 gene knockout cell lines are invaluable in understanding disease mechanisms and developing targeted therapies.

Unique to our MAPK3 gene knockout cell lines is their high specificity and reliability, which stem from CRISPR/Cas9 gene-editing technology. This method ensures precise gene disruption, leading to reproducible experimental outcomes. Compared to traditional gene silencing methods such as siRNA technology, which often produces transient effects, our knockout cell lines provide a stable and long-term model that supports extensive experimentation.

For researchers and clinicians, these cell lines offer significant advantages by facilitating hypothesis-driven studies on MAPK3 functions. Their application can lead to breakthroughs in therapeutic strategies, ultimately advancing the field of biomedical research. Furthermore, researchers can utilize these cell lines to validate new drug candidates, making it easier to move from bench to bedside.

Our commitment to quality and innovation in biological research products is backed by extensive expertise in genetic engineering and cell line development. We strive to equip researchers with the highest standard tools needed to push the boundaries of knowledge and improve clinical outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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