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MAOB Knockout Cell Lines

Gene: MAOB

Official Full Name: monoamine oxidase Bprovided by HGNC

Gene Summary: The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04530 MAOB Knockout cell line (HeLa) Human MAOB 1:3~1:6 Negative Online Inquiry
KO04531 MAOB Knockout cell line (HCT 116) Human MAOB 1:2~1:4 Negative Online Inquiry

Background

MAOB Gene Knockout Cell Lines are advanced research tools designed to facilitate the investigation of monoamine oxidase B (MAOB) function and its implications in neurobiology and various pathological conditions. These genetically modified cell lines exhibit a complete deletion of the MAOB gene, enabling researchers to study the cellular and molecular consequences of MAOB deficiency without the complexities introduced by wild-type gene expression.

The key function of these cell lines lies in their ability to provide a controlled environment for exploring the physiological roles of MAOB, particularly in the context of neurotransmitter metabolism, oxidative stress, and neurodegenerative diseases. By utilizing these knockout models, scientists can observe the resultant alterations in metabolic pathways, mitochondrial function, and cellular responses to stressors, thus shedding light on the intricate mechanisms that link MAOB to disorders such as Parkinson's disease and mood disorders.

In the scientific community, the importance of MAOB Gene Knockout Cell Lines extends into both research and clinical applications. They serve as invaluable models for drug discovery, allowing for the assessment of MAO inhibitors' efficacy, mechanisms, and potential side effects. Moreover, these cell lines provide a platform for screening neuroprotective agents, helping identify new therapeutic strategies to mitigate neuronal degeneration.

Compared to traditional cell lines, our MAOB Gene Knockout Cell Lines offer a unique advantage by providing a clean genetic background that eliminates confounding MAOB activity. This specificity ensures that experimental outcomes are more reliable and reproducible, facilitating greater confidence in data interpretation.

Researchers and clinicians alike will find these cell lines invaluable for advancing understanding in pharmacology, neurobiology, and toxicology. By employing our MAOB Gene Knockout Cell Lines, users can enhance their exploration of MAOB-related mechanisms, potentially leading to breakthroughs in therapeutic development and improved patient outcomes.

At [Your Company Name], we pride ourselves on developing high-quality, robust biological products. Our expertise in gene editing technology and commitment to scientific excellence ensures that our researchers have access to the most innovative and effective tools for advancing their research agendas.

Please note that all services are for research use only. Not intended for any clinical use.

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