Gene: MAGEE1
Official Full Name: MAGE family member E1provided by HGNC
Gene Summary: This gene encodes an alpha-dystrobrevin-associated MAGE (melanoma-associated antigen) protein, which is a member of the MAGE family. The protein contains a nuclear localization signal in the N-terminus, 30 12-amino acid repeats beginning at nt 60 with the consensus sequence ASEGPSTSVLPT, and two MAGE domains in the C-terminus. It may play a signaling role in brain, muscle, and peripheral nerve. This gene is located on X chromosome in a region containing loci linked to cognitive disability. [provided by RefSeq, Mar 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO16387 | MAGEE1 Knockout cell line (HCT 116) | Human | MAGEE1 | 1:2~1:4 | Negative | Online Inquiry |
KO16388 | MAGEE1 Knockout cell line (A549) | Human | MAGEE1 | 1:3~1:4 | Negative | Online Inquiry |
MAGEE1 Gene Knockout Cell Lines are genetically engineered cell lines designed specifically to facilitate the study of the MAGEE1 gene's functions and implications in various biological processes and diseases. The MAGEE1 gene is part of the cancer/testis (CT) antigen family and has been implicated in numerous oncogenic pathways, making its investigation crucial for understanding tumorigenesis and potential therapeutic targets.
These knockout cell lines utilize advanced CRISPR-Cas9 technology to effectively create precise gene deletions, allowing researchers to study the loss-of-function effects of the MAGEE1 gene in a controlled environment. By comparing these knockout lines with wild-type counterparts, scientists can elucidate cellular mechanisms in processes such as cell proliferation, apoptosis, and immune evasion. This precise gene-editing approach guarantees high specificity and efficiency, making it a reliable method for genetic manipulation and functional studies.
The scientific importance of MAGEE1 Gene Knockout Cell Lines extends into both research and clinical applications. In research settings, they serve as invaluable tools for exploring the gene's role in tumor biology and identifying potential biomarkers for cancer detection. Clinically, insights derived from these studies can inform novel therapeutic strategies, including the development of targeted immunotherapies aimed at cancers expressing MAGEE1 antigens.
Compared to alternative gene knockout technologies, the MAGEE1 Gene Knockout Cell Lines stand out due to their ease of use, reproducibility, and the robustness of the systems. Unlike older methods that may rely on transient expression of shRNA or other less efficient gene-silencing techniques, our stable knockout lines offer consistent and long-term analysis of gene function.
For researchers and clinicians, the value of these cell lines lies in their ability to accelerate the discovery of novel insights into cancer biology, ultimately contributing to more effective treatment options. Our company's commitment to innovation and quality in producing these specialized cell lines is backed by years of expertise in biological product development, ensuring that our customers receive the highest standard of research tools to support their critical work in understanding and combating diseases.
Please note that all services are for research use only. Not intended for any clinical use.
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