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MAD1L1 Knockout Cell Lines

Gene: MAD1L1

Official Full Name: mitotic arrest deficient 1 like 1provided by HGNC

Gene Summary: MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06988 MAD1L1 Knockout cell line (HeLa) Human MAD1L1 1:3~1:6 Negative Online Inquiry
KO06989 MAD1L1 Knockout cell line (HCT 116) Human MAD1L1 1:2~1:4 Negative Online Inquiry
KO06990 MAD1L1 Knockout cell line (HEK293) Human MAD1L1 1:3~1:6 Negative Online Inquiry
KO06991 MAD1L1 Knockout cell line (A549) Human MAD1L1 1:3~1:4 Negative Online Inquiry

Background

MAD1L1 Gene Knockout Cell Lines are genetically engineered cell lines designed to specifically disrupt the MAD1L1 gene, which plays a pivotal role in crucial cellular processes such as cell cycle regulation and DNA repair mechanisms. By inducing a targeted knockout of this gene, researchers can effectively study the downstream effects of MAD1L1 loss, facilitating a deeper understanding of its involvement in various diseases, including cancer and genetic disorders.

The primary mechanism of action in MAD1L1 Gene Knockout Cell Lines involves the use of CRISPR-Cas9 technology, an advanced genome-editing tool that allows for precise modifications in the DNA sequence. This powerful technique enables the creation of cell lines that exhibit reliable and reproducible deletion of the MAD1L1 gene, providing a robust platform for investigating alterations in cell proliferation, apoptosis, and genomic stability.

In the realm of scientific research, the MAD1L1 Gene Knockout Cell Lines hold significant importance. They serve as a critical model for studying the pathogenesis of diseases associated with MAD1L1 dysregulation, as well as for drug discovery and therapeutic development. Moreover, these cell lines can be readily utilized in functional assays, facilitating the exploration of potential interactions with other cellular pathways.

One of the key advantages of our MAD1L1 Gene Knockout Cell Lines is their high specificity and ease of use compared to other gene manipulation methods. Unlike traditional gene knockdown techniques that may suffer from off-target effects, CRISPR-based knockouts provide unmatched precision, ensuring that researchers can focus on the consequences of MAD1L1 disruption without confounding variables. Additionally, our cell lines come with comprehensive protocols and support, enabling efficient integration into various laboratory workflows.

For researchers and clinicians, the ability to utilize MAD1L1 Gene Knockout Cell Lines represents a value-added resource in dissecting the complexities of gene function and disease mechanisms. Whether investigating novel therapeutic targets or elucidating cellular responses to various stimuli, these cell lines offer unparalleled insights into the biological roles of the MAD1L1 gene.

As a company dedicated to advancing biomedical research, our expertise lies in providing high-quality genetic models, including these specialized knockout cell lines. We prioritize scientific rigor and innovation, ensuring that our products contribute meaningfully to the pursuit of knowledge in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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