Gene: LYN
Official Full Name: LYN proto-oncogene, Src family tyrosine kinaseprovided by HGNC
Gene Summary: This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO11053 | LYN Knockout cell line (HeLa) | Human | LYN | 1:3~1:6 | Negative | Online Inquiry |
KO11054 | LYN Knockout cell line (HCT 116) | Human | LYN | 1:2~1:4 | Negative | Online Inquiry |
KO11055 | LYN Knockout cell line (HEK293) | Human | LYN | 1:3~1:6 | Negative | Online Inquiry |
KO11056 | LYN Knockout cell line (A549) | Human | LYN | 1:3~1:4 | Negative | Online Inquiry |
LYN Gene Knockout Cell Lines are specialized cell culture systems designed to enable researchers to investigate the functional role of the LYN gene and its associated signaling pathways. The LYN gene encodes a member of the Src family of protein tyrosine kinases, which have critical roles in cell proliferation, differentiation, and immune responses. By utilizing CRISPR/Cas9 technology, these cell lines effectively achieve complete knockout of the LYN gene, allowing for detailed analysis of its downstream effects and interactions with various cellular processes.
The key function of LYN Gene Knockout Cell Lines lies in their ability to facilitate the study of LYN's involvement in disease states, particularly in hematological malignancies such as leukemia and lymphoma. The knockout mechanism disrupts the expression of LYN protein, enabling researchers to assess phenotypic changes, signaling cascades, and altered gene expression profiles resulting from this genetic modification. This provides valuable insights into the pathophysiology of diseases and helps identify potential therapeutic targets.
Scientifically, these cell lines are significant for academic and clinical research settings. They serve as a fundamental tool for drug screening, biomarker discovery, and understanding tumor microenvironments. Researchers can employ these cells to elucidate the effects of various pharmacological agents, as well as to validate LYN as a target for novel cancer therapies. Compared to other alternatives, LYN Gene Knockout Cell Lines offer unparalleled specificity in studying the LYN gene's function without the confounding effects present in heterozygous or partial knockout models.
The advantages of these cell lines include their robust reproducibility and high-quality maintenance, providing a dependable platform that enhances experimental outcomes. Moreover, these knockout models can accelerate research timelines, helping labs achieve breakthroughs faster and with greater confidence.
By choosing LYN Gene Knockout Cell Lines, researchers and clinicians are investing in a powerful asset that will facilitate innovative discoveries within the fields of cancer research and molecular biology. Our company specializes in the production of high-quality gene knockout models, backed by years of expertise and commitment to advancing scientific inquiry.
Please note that all services are for research use only. Not intended for any clinical use.
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