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LRP1B Knockout Cell Lines

Gene: LRP1B

Official Full Name: LDL receptor related protein 1Bprovided by HGNC

Gene Summary: This gene encodes a member of the low density lipoprotein (LDL) receptor family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. Disruption of this gene has been reported in several types of cancer. [provided by RefSeq, Jun 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO21964 LRP1B Knockout cell line (HeLa) Human LRP1B 1:3~1:6 Negative Online Inquiry
KO21965 LRP1B Knockout cell line (HEK293) Human LRP1B 1:3~1:6 Negative Online Inquiry

Background

LRP1B Gene Knockout Cell Lines are genetically modified cell lines specifically engineered to lack the expression of the low-density lipoprotein receptor-related protein 1B (LRP1B). This gene plays a crucial role in lipid metabolism, cellular signaling, and various disease processes, including cancer progression and neurodegenerative disorders. The knockout of LRP1B allows researchers to investigate its functional implications, enabling a deeper understanding of the pathways involved in these conditions.

These cell lines operate through the absence of LRP1B, leading to alterations in cellular uptake of lipoproteins and impacting key signaling cascades, such as the modulation of endocytosis and cytokine signaling. By leveraging this knockout model, scientists can elucidate the gene’s contribution to various biological processes and disease mechanisms, thereby supporting the development of targeted therapies. Their importance in research settings extends to oncology, neurobiology, and metabolic studies, where understanding LRP1B-related pathways can lead to breakthroughs in disease management.

What sets LRP1B Gene Knockout Cell Lines apart from traditional models is their specificity and precision in gene modulation. Unlike pharmacological inhibitors that may have off-target effects, these genetically modified cell lines provide a cleaner and more reliable approach for studying the gene's function, allowing for precise conclusions regarding biological mechanisms. Furthermore, their robust capability in varied experimental conditions makes them essential tools for high-throughput screening and drug discovery initiatives.

For researchers and clinicians, the value of LRP1B Gene Knockout Cell Lines lies in their capacity to enhance the understanding of complex biological processes and facilitate the identification of novel therapeutic targets. By utilizing these cell lines, users gain access to a powerful resource that can drive innovative research and contribute to significant advancements in clinical applications.

Our company specializes in providing high-quality biological products that meet rigorous scientific standards. With a commitment to excellence and a deep understanding of molecular biology, we ensure our offerings, including LRP1B Gene Knockout Cell Lines, are equipped to support your research endeavors effectively and efficiently.

Please note that all services are for research use only. Not intended for any clinical use.

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