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LMNB2 Knockout Cell Lines

Gene: LMNB2

Official Full Name: lamin B2provided by HGNC

Gene Summary: This gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy. [provided by RefSeq, May 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO24600 LMNB2 Knockout cell line (HeLa) Human LMNB2 1:3~1:6 Negative Online Inquiry
KO24601 LMNB2 Knockout cell line (HCT 116) Human LMNB2 1:2~1:4 Negative Online Inquiry
KO24602 LMNB2 Knockout cell line (HEK293) Human LMNB2 1:3~1:6 Negative Online Inquiry
KO24603 LMNB2 Knockout cell line (A549) Human LMNB2 1:3~1:4 Negative Online Inquiry

Background

LMNB2 Gene Knockout Cell Lines are a specialized biological tool designed to study the functions of the LMNB2 gene, which encodes for lamin B2, an integral component of the nuclear lamina. This product facilitates targeted gene disruption resulting in cell lines wherein the LMNB2 gene is non-functional. The precise knockout methodology leverages CRISPR/Cas9 gene-editing technology, allowing for accurate and stable genetic modification. These cell lines serve as powerful models for investigating the role of lamin B2 in nuclear structure and function, cell cycle regulation, and cellular response to stress.

The key mechanisms of LMNB2 Gene Knockout Cell Lines involve the disruption of nuclear envelope integrity and organization, leading to observable biological phenotypes. Researchers can utilize these models to elucidate the implications of lamin B2 deficiency in various cellular processes, with potential links to diseases such as cancer and neurodegenerative disorders.

In both research and clinical applications, these knockout cell lines are invaluable for drug discovery, biomarker identification, and the development of therapeutic strategies targeting LMNB2-related pathologies. Their use extends to elucidating fundamental biological processes such as gene expression regulation, chromatin organization, and cellular aging, providing insights that are critical for advancing both basic and applied sciences.

What sets LMNB2 Gene Knockout Cell Lines apart from alternatives is their specifically engineered design, providing researchers with a robust and reliable platform for in-depth studies. These cell lines are rigorously validated for functionality and stability, ensuring reproducibility in experimental outcomes.

Our company's expertise in biotechnology and gene editing is reflected in the quality and reliability of our biological products. We are committed to providing cutting-edge solutions that empower scientists and clinicians in their quest for innovative breakthroughs in life sciences. By integrating state-of-the-art technology with a deep understanding of molecular biology, we deliver products that significantly enhance research capabilities and clinical applications.

Please note that all services are for research use only. Not intended for any clinical use.

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