Gene: LFNG
Official Full Name: LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferaseprovided by HGNC
Gene Summary: This gene is a member of the glycosyltransferase 31 gene family. Members of this gene family, which also includes the MFNG (GeneID: 4242) and RFNG (GeneID: 5986) genes, encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, these proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. The protein encoded by this gene is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150). Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3. [provided by RefSeq, May 2018]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO07208 | LFNG Knockout cell line (HeLa) | Human | LFNG | 1:3~1:6 | Negative | Online Inquiry |
KO07209 | LFNG Knockout cell line (HCT 116) | Human | LFNG | 1:2~1:4 | Negative | Online Inquiry |
KO07210 | LFNG Knockout cell line (A549) | Human | LFNG | 1:3~1:4 | Negative | Online Inquiry |
LFNG Gene Knockout Cell Lines are advanced biological tools specifically engineered to facilitate the study of the LFNG gene, known for its critical role in the glycosylation of proteins and modulation of signaling pathways during cellular processes. These cell lines have been meticulously developed using CRISPR-Cas9 technology to achieve a complete knockout of the LFNG gene, allowing researchers to observe the resultant phenotypic changes and better understand the gene's function in various biological contexts.
The key mechanism behind these knockout cell lines lies in their inability to express the LFNG protein, which interrupts normal cellular processes such as Notch signaling and influences stem cell differentiation. By utilizing these cell lines, researchers can delve into the molecular underpinnings associated with LFNG-related cellular pathways, making them invaluable for studies focused on developmental biology, cancer research, and regenerative medicine.
The scientific importance of LFNG Gene Knockout Cell Lines in both research and clinical settings cannot be overstated. They enable precise investigations into how LFNG contributes to diseases related to aberrant signaling pathways, offering potential insights for therapeutic targets and the development of novel treatments. In contrast to alternatives, such as transient knockdown methods that may lack specificity, LFNG knockout lines provide a stable and permanent solution, ensuring reproducibility and reliability in experimental outcomes.
Offering unparalleled value, these cell lines are a crucial asset to researchers and clinicians aiming to unlock the complexities of gene function and disease mechanisms. Enhanced insights derived from such studies can lead to significant advancements in biomedical research and therapeutic innovations.
By choosing our LFNG Gene Knockout Cell Lines, you are partnering with a company dedicated to excellence in life sciences, grounded in extensive expertise in gene editing technologies and cellular biology. Our commitment to quality ensures that you receive products that not only meet the highest scientific standards but also advance your research objectives.
Please note that all services are for research use only. Not intended for any clinical use.
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