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LCN2 Knockout Cell Lines

Gene: LCN2

Official Full Name: lipocalin 2provided by HGNC

Gene Summary: This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. The presence of this protein in blood and urine is an early biomarker of acute kidney injury. This protein is thought to be be involved in multiple cellular processes, including maintenance of skin homeostasis, and suppression of invasiveness and metastasis. Mice lacking this gene are more susceptible to bacterial infection than wild type mice. [provided by RefSeq, Sep 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO09495 LCN2 Knockout cell line (HCT 116) Human LCN2 1:2~1:4 Negative Online Inquiry
KO09496 LCN2 Knockout cell line (A549) Human LCN2 1:3~1:4 Negative Online Inquiry

Background

LCN2 Gene Knockout Cell Lines are genetically engineered cellular models that have been developed to lack the expression of the lipocalin 2 (LCN2) gene. LCN2, also known as 24p3, is involved in iron homeostasis, immune response, and various metabolic pathways. The precise knockout of this gene provides researchers with a unique tool to explore and understand the multifunctional roles of LCN2 in both physiological and pathological conditions.

These knockout cell lines allow for detailed investigation of the mechanistic pathways through which LCN2 influences cellular behaviors, such as proliferation, differentiation, and apoptosis. By employing CRISPR-Cas9 gene-editing technology, these cell lines not only eliminate the compensatory mechanisms often encountered in traditional knockout models but also enhance reproducibility and specificity in experimental setups. Researchers can utilize these models to study conditions such as cancer, inflammation, and neurodegenerative diseases, where LCN2 has been linked to altered cellular responses.

One of the significant advantages of LCN2 Gene Knockout Cell Lines is their capacity to provide insights that are otherwise obscured by the presence of LCN2 in wild-type cells. Additionally, these cell lines can complement diverse in vitro assays and biotherapeutic development efforts, thereby streamlining research workflows and contributing to faster turnaround times for experimental outcomes. Compared to existing models that may leave compensatory pathways unexamined, these knockout lines offer a precise approach to elucidate the implications of LCN2 absence.

For researchers and clinicians alike, the value of LCN2 Gene Knockout Cell Lines lies in their versatility and the depth of biological knowledge they facilitate. As a product offered by our company, which specializes in the development of high-quality genetic models for research and therapeutic applications, LCN2 Gene Knockout Cell Lines embody our commitment to advancing scientific discovery and providing reliable solutions for the biomedical community.

Please note that all services are for research use only. Not intended for any clinical use.

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