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LATS1 Knockout Cell Lines

Gene: LATS1

Official Full Name: large tumor suppressor kinase 1provided by HGNC

Gene Summary: The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08581 LATS1 Knockout cell line (HeLa) Human LATS1 1:3~1:6 Negative Online Inquiry
KO08582 LATS1 Knockout cell line (HCT 116) Human LATS1 1:2~1:4 Negative Online Inquiry
KO08583 LATS1 Knockout cell line (HEK293) Human LATS1 1:3~1:6 Negative Online Inquiry
KO08584 LATS1 Knockout cell line (A549) Human LATS1 1:3~1:4 Negative Online Inquiry

Background

LATS1 Gene Knockout Cell Lines are specialized cellular models engineered to lack the LATS1 gene, a critical component of the Hippo signaling pathway, which plays a pivotal role in regulating cell proliferation and survival. By disrupting the LATS1 gene, these cell lines provide researchers with a powerful tool for investigating the downstream effects and biological functions of this signaling cascade, particularly in contexts such as cancer, tissue development, and organ hypertrophy.

The primary function of LATS1 is to act as a tumor suppressor; it inhibits cell growth and promotes apoptosis in response to certain signals. In LATS1 knockout models, researchers can elucidate the gene's role in cellular processes and examine the consequences of its absence, including unchecked cellular proliferation and potential oncogenesis. This valuable insight is instrumental when studying the mechanisms of various diseases, allowing for a better understanding of tumor biology and the development of targeted therapies.

In scientific research and clinical applications, LATS1 Gene Knockout Cell Lines stand out for their unique capability to model conditions that mimic the loss of LATS1 function. These cell lines are essential for high-throughput screening, drug discovery, and functional genomics, providing results that are highly relevant to cancer biology and regenerative medicine. Compared to other models, such as transient gene knockdowns or overexpression systems, the knockout approach offers a more stable and reliable platform for physiological studies.

Researchers and clinicians will find these cell lines particularly valuable for their reproducibility and ability to reflect natural biological conditions, which are critical for translational research. By utilizing LATS1 Gene Knockout Cell Lines, the scientific community can accelerate the pace of discovery in understanding the roles of the Hippo pathway in various diseases.

Our company is committed to advancing biological research through high-quality cellular models. With a deep expertise in gene editing technologies and a focus on precision, we offer a robust portfolio of knockout cell lines that empower researchers to achieve breakthrough results in their studies.

Please note that all services are for research use only. Not intended for any clinical use.

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