Gene: LASP1
Official Full Name: LIM and SH3 protein 1provided by HGNC
Gene Summary: This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36849 | LASP1 Knockout cell line (HeLa) | Human | LASP1 | 1:3~1:6 | Negative | Online Inquiry |
KO36850 | LASP1 Knockout cell line (HCT 116) | Human | LASP1 | 1:2~1:4 | Negative | Online Inquiry |
KO36851 | LASP1 Knockout cell line (HEK293) | Human | LASP1 | 1:3~1:6 | Negative | Online Inquiry |
KO36852 | LASP1 Knockout cell line (A549) | Human | LASP1 | 1:3~1:4 | Negative | Online Inquiry |
LASP1 Gene Knockout Cell Lines represent a groundbreaking advancement in the study of cancer biology and cellular mechanisms. These cell lines have been genetically engineered to completely disrupt the LASP1 gene, which encodes for the LIM and SH3 protein that plays a critical role in actin cytoskeleton organization and cellular signaling pathways. By selectively knocking out LASP1, researchers can meticulously observe the resulting phenotypic alterations, essential for understanding its contributions to cell proliferation, migration, and tumor metastasis.
The primary function of these knockout cell lines lies in their ability to facilitate in-depth studies into LASP1's role in various cellular processes. The loss of LASP1 has been associated with significant shifts in actin dynamics, influencing cellular adhesion and motility, which are crucial for tumor invasion and spread. By utilizing these cell lines, scientists can explore potential therapeutic targets for interventions in LASP1-mediated pathways, ultimately paving the way for innovative cancer treatments.
In terms of scientific importance, LASP1 gene knockout cell lines have applications spanning basic research to clinical investigations. They can be utilized in drug discovery efforts to identify novel agents that specifically target LASP1-related mechanisms, providing a concrete foundation for translational research aimed at developing effective cancer therapies. Furthermore, these models can help elucidate the interplay between LASP1 and tumor microenvironments, expanding our understanding of tumor biology.
What sets LASP1 Gene Knockout Cell Lines apart from traditional models is their specificity and precision in gene editing, ensuring reliable reproducibility of results. This level of targeted manipulation allows for more accurate investigations into the biochemical pathways influenced by LASP1, unlike conventional methods that may yield ambiguous data or require extensive validation.
Researchers, clinicians, and pharmaceutical developers will find these cell lines invaluable, as they not only deepen the knowledge of cancer biology but also offer potential pathways for therapeutic discovery. By using our LASP1 Gene Knockout Cell Lines, users can anticipate significant contributions to their research and clinical outcomes, positioning them at the forefront of cancer research.
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Please note that all services are for research use only. Not intended for any clinical use.
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