Gene: LAMA3
Official Full Name: laminin subunit alpha 3provided by HGNC
Gene Summary: The protein encoded by this gene belongs to the laminin family of secreted molecules. Laminins are heterotrimeric molecules that consist of alpha, beta, and gamma subunits that assemble through a coiled-coil domain. Laminins are essential for formation and function of the basement membrane and have additional functions in regulating cell migration and mechanical signal transduction. This gene encodes an alpha subunit and is responsive to several epithelial-mesenchymal regulators including keratinocyte growth factor, epidermal growth factor and insulin-like growth factor. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa and laryngoonychocutaneous syndrome. Alternative splicing and alternative promoter usage result in multiple transcript variants. [provided by RefSeq, Dec 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10270 | LAMA3 Knockout cell line (HeLa) | Human | LAMA3 | 1:3~1:6 | Negative | Online Inquiry |
KO10271 | LAMA3 Knockout cell line (HCT 116) | Human | LAMA3 | 1:2~1:4 | Negative | Online Inquiry |
KO10272 | LAMA3 Knockout cell line (HEK293) | Human | LAMA3 | 1:3~1:6 | Negative | Online Inquiry |
KO10273 | LAMA3 Knockout cell line (A549) | Human | LAMA3 | 1:3~1:4 | Negative | Online Inquiry |
LAMA3 Gene Knockout Cell Lines are engineered cell lines specifically designed to eliminate the expression of the LAMA3 gene, which encodes for the laminin subunit alpha 3—an essential component of the extracellular matrix involved in cell adhesion, migration, and cellular proliferation. By inducing a targeted knockout of this gene, researchers can investigate the functional role of LAMA3 in various biological processes and diseases, notably tissue engineering, cancer biology, and developmental studies.
These cell lines facilitate the study of complex cellular behaviors and signaling pathways impacted by the absence of LAMA3. The knockout mechanism typically involves CRISPR/Cas9 technology or RNA interference, offering precise gene-editing capabilities that induce significant phenotypic changes in the cells. This allows researchers to dissect the molecular dynamics underlying cellular interactions and identify potential therapeutic targets in cancer and regenerative medicine.
The scientific importance of LAMA3 Gene Knockout Cell Lines is underscored by their applications in understanding the pathogenesis of diseases associated with extracellular matrix dysfunction, including several forms of cancer and genetic disorders. The data generated from these cell lines can lead to promising advancements in drug discovery and the development of novel therapeutic approaches.
What sets our LAMA3 Gene Knockout Cell Lines apart from alternatives is our commitment to quality and reproducibility; each cell line is thoroughly validated for gene knockout efficiency, cell viability, and functional assays. This rigor ensures that researchers receive reliable data that accelerates their projects and enhances the robustness of their findings.
For researchers and clinicians seeking to unravel the complexities of cellular biology or develop innovative treatment options, our LAMA3 Gene Knockout Cell Lines provide a powerful tool that marries precision with functional relevance. Our company brings years of expertise in cell line development and gene editing, ensuring that our products meet the highest standards of reliability and performance. By choosing our offerings, researchers are not only acquiring exceptional biological tools but also collaborating with a leader in the field of molecular biology.
Please note that all services are for research use only. Not intended for any clinical use.
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