Gene: KLHL23
Official Full Name: kelch like family member 23provided by HGNC
Gene Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in membrane. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO21993 | KLHL23 Knockout cell line (HeLa) | Human | KLHL23 | 1:3~1:6 | Negative | Online Inquiry |
KO21994 | KLHL23 Knockout cell line (HCT 116) | Human | KLHL23 | 1:2~1:4 | Negative | Online Inquiry |
KO21995 | KLHL23 Knockout cell line (HEK293) | Human | KLHL23 | 1:3~1:6 | Negative | Online Inquiry |
KO21996 | KLHL23 Knockout cell line (A549) | Human | KLHL23 | 1:3~1:4 | Negative | Online Inquiry |
KLHL23 Gene Knockout Cell Lines are meticulously engineered cellular models designed to facilitate the study of KLHL23, a gene implicated in various biological processes, including protein ubiquitination and cellular signaling pathways. These cell lines are generated through CRISPR-Cas9 technology, allowing for precise gene editing that results in the complete knockout of KLHL23, thereby enabling researchers to investigate the functional consequences of its absence.
The primary function of KLHL23 Gene Knockout Cell Lines is to provide a platform for examining the role of KLHL23 in cellular mechanisms, including its contributions to cellular homeostasis, proliferation, and responses to stress. Researchers can utilize these cell lines to assess changes in gene expression profiles, protein interactions, and cellular behaviors compared to wild-type counterparts. This capability is vital for uncovering the biological significance of KLHL23 in various contexts, such as cancer biology, neurodegenerative diseases, and immunological responses.
The scientific importance of these knockout cell lines extends to both basic and applied research settings, making them valuable tools in drug discovery and development. Understanding the role of KLHL23 can lead to novel therapeutic strategies for diseases where this protein is implicated. By using these cellular models, scientists can identify potential biomarkers and therapeutic targets, paving the way for advancements in precision medicine.
Compared to alternative methods of gene manipulation, such as RNA interference or traditional knockout techniques, KLHL23 Gene Knockout Cell Lines offer several unique advantages. The CRISPR-Cas9 approach provides greater specificity and efficiency, minimizing off-target effects and allowing for robust characterization of gene functions. Additionally, these cell lines are readily adaptable for various experimental frameworks, including high-throughput screening and in vivo studies.
For researchers and clinicians alike, KLHL23 Gene Knockout Cell Lines represent a critical asset for dissecting the intricate networks of cellular regulation. Their availability enables quicker and more thorough investigations into gene functionality, facilitating breakthroughs in understanding disease mechanisms. Our company excels in the development of advanced genetic models, with a commitment to providing high-quality, cutting-edge products that empower scientific discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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