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KLHL21 Knockout Cell Lines

Gene: KLHL21

Official Full Name: kelch like family member 21provided by HGNC

Gene Summary: Enables cullin family protein binding activity. Contributes to ubiquitin-protein transferase activity. Involved in chromosome passenger complex localization to spindle midzone; protein ubiquitination; and regulation of cytokinesis. Located in polar microtubule. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32547 KLHL21 Knockout cell line (HeLa) Human KLHL21 1:3~1:6 Negative Online Inquiry
KO32548 KLHL21 Knockout cell line (HCT 116) Human KLHL21 1:2~1:4 Negative Online Inquiry
KO32549 KLHL21 Knockout cell line (HEK293) Human KLHL21 1:3~1:6 Negative Online Inquiry
KO32550 KLHL21 Knockout cell line (A549) Human KLHL21 1:3~1:4 Negative Online Inquiry

Background

KLHL21 Gene Knockout Cell Lines represent a novel tool for investigating the biological functions and pathways regulated by the KLHL21 gene, which encodes a member of the Kelch-like protein family involved in proteasome-mediated degradation and cellular signaling processes. These cell lines have been precisely engineered to disrupt the KLHL21 gene via CRISPR-Cas9 technology, enabling researchers to study the gene's role in various cellular contexts, including cell cycle regulation, protein homeostasis, and stress response mechanisms.

The primary function of KLHL21 Gene Knockout Cell Lines lies in their ability to elucidate the molecular underpinnings associated with KLHL21-related pathologies, including neurodegenerative diseases and certain cancers. By utilizing these cell lines in functional assays, researchers can manipulate and observe cellular responses to KLHL21 knockout, thereby understanding its role in disease progression or therapeutic resilience. The applicability in research is broad-ranging, with potential experiments designed to explore gene-environment interactions, drug responses, and effective patient stratification in clinical settings.

What sets KLHL21 Gene Knockout Cell Lines apart from alternative products is their precision and ease of use; they are fully characterized, validated, and ready for immediate experimentation. Additionally, the knockouts are generated under stringent quality controls, ensuring reproducibility and reliability across various research applications. This product empowers researchers and clinicians to generate data with higher accuracy while saving time and resources, keys to advancing scientific discovery.

Incorporating KLHL21 Gene Knockout Cell Lines into research could significantly enhance the understanding of gene function and regulation, translating into better therapeutic targets and intervention strategies. With a robust foundation in genetic engineering and a commitment to advancing biotechnological solutions, our company is dedicated to providing leading-edge products that support groundbreaking research in molecular biology and medicine.

Please note that all services are for research use only. Not intended for any clinical use.

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