Gene: KLHDC10
Official Full Name: kelch domain containing 10provided by HGNC
Gene Summary: Enables ubiquitin-like ligase-substrate adaptor activity. Involved in rescue of stalled ribosome and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Located in nucleoplasm. Is active in Cul2-RING ubiquitin ligase complex and cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO30037 | KLHDC10 Knockout cell line (HeLa) | Human | KLHDC10 | 1:3~1:6 | Negative | Online Inquiry |
KO30038 | KLHDC10 Knockout cell line (HCT 116) | Human | KLHDC10 | 1:2~1:4 | Negative | Online Inquiry |
KO30039 | KLHDC10 Knockout cell line (HEK293) | Human | KLHDC10 | 1:3~1:6 | Negative | Online Inquiry |
KO30040 | KLHDC10 Knockout cell line (A549) | Human | KLHDC10 | 1:3~1:4 | Negative | Online Inquiry |
KLHDC10 Gene Knockout Cell Lines are specifically engineered cellular models that enable the study of the KLHDC10 gene’s function by removing its expression through the established CRISPR/Cas9 genome-editing technique. These cell lines provide a powerful tool for examining gene interactions, pathways, and the resultant phenotypic effects associated with the absence of KLHDC10. This knockout model allows researchers to delve into the role of KLHDC10 in various cellular processes, such as protein degradation, cellular stress responses, and potential implications in disease mechanisms.
The key function of KLHDC10 Gene Knockout Cell Lines lies in their ability to facilitate investigations into the gene’s biological impact. By using these knockout models, researchers can explore the effects of KLHDC10 deficiency on cell growth, survival, and response to treatments, providing insights that are critical for understanding its role in pathologies, including certain cancers and metabolic disorders. Additionally, these cell lines can serve as versatile platforms for drug discovery, toxicity testing, and functional genomics, thereby enhancing their significance in clinical and translational research.
A notable advantage of using KLHDC10 Gene Knockout Cell Lines is their specificity and reproducibility compared to traditional methods such as RNA interference, which can yield off-target effects and variable knockdown efficiency. These knockout lines ensure complete gene ablation and allow for more straightforward interpretations of experimental results, making them a preferred choice for researchers seeking reliable data.
Researchers and clinicians stand to gain significantly from the application of these knockout cell lines as they accelerate the understanding of disease mechanisms and therapeutic targets, contributing to the development of innovative treatment strategies and enhancing precision medicine approaches.
At our company, we pride ourselves on our extensive expertise in developing high-quality biological research tools, ensuring our KLHDC10 Gene Knockout Cell Lines are rigorously validated and supported by comprehensive documentation for optimal performance in your research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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