Gene: KLF14
Official Full Name: KLF transcription factor 14provided by HGNC
Gene Summary: This intronless gene encodes a member of the Kruppel-like family of transcription factors. The encoded protein functions as a transcriptional co-repressor, and is induced by transforming growth factor-beta (TGF-beta) to repress TGF-beta receptor II gene expression. This gene exhibits imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. [provided by RefSeq, Jul 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01461 | KLF14 Knockout cell line(BEL-7402) | Human | KLF14 | Negative | Online Inquiry |
KLF14 Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate the exploration of the KLF14 gene's role in cellular processes and disease mechanisms. KLF14, a member of the Kruppel-like factor family of transcription factors, is implicated in metabolic regulation and has associations with various health conditions, including diabetes and obesity. By utilizing CRISPR-Cas9 technology, these cell lines provide a robust platform for investigating gene function and the downstream effects of KLF14 knockout in a controlled in vitro environment.
The primary function of KLF14 Gene Knockout Cell Lines is to enable researchers to elucidate the pathways mediated by KLF14 and assess the resultant phenotypic changes. By knocking out this gene, scientists can observe alterations in cellular metabolism, adipocyte differentiation, and insulin sensitivity, thereby identifying potential therapeutic targets for metabolic disorders. These studies are crucial for advancing our understanding of the molecular underpinnings of metabolic diseases, making these cell lines vital tools in both basic and translational research.
In comparison to traditional wild-type models, KLF14 Gene Knockout Cell Lines offer several unique advantages. They provide enhanced specificity in gene function studies and reduce variability, which is often seen in genetically heterogeneous populations. Furthermore, the use of knockout models allows for clearer mechanistic insights, enabling faster and more targeted drug discovery efforts than conventional methods.
The value of KLF14 Gene Knockout Cell Lines to researchers and clinicians lies not only in their precision and reliability but also in the potential for breakthroughs that could lead to novel therapeutic avenues for treating metabolic diseases. By utilizing these advanced cell lines, users can significantly accelerate their research while contributing to the wider understanding of the KLF14 gene's clinical implications.
Our company is dedicated to advancing scientific knowledge through high-quality biological products. With expertise in gene-editing technologies and a commitment to innovation, we provide researchers with the tools necessary for impactful discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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