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KLF11 Knockout Cell Lines

Gene: KLF11

Official Full Name: KLF transcription factor 11provided by HGNC

Gene Summary: The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO34162 KLF11 Knockout cell line (HeLa) Human KLF11 1:3~1:6 Negative Online Inquiry
KO34163 KLF11 Knockout cell line (HCT 116) Human KLF11 1:2~1:4 Negative Online Inquiry
KO34164 KLF11 Knockout cell line (HEK293) Human KLF11 1:3~1:6 Negative Online Inquiry
KO34165 KLF11 Knockout cell line (A549) Human KLF11 1:3~1:4 Negative Online Inquiry

Background

KLF11 Gene Knockout Cell Lines are specifically engineered cellular models designed for the study of the Krüppel-like factor 11 (KLF11) gene, which plays a pivotal role in various physiological processes, including glucose metabolism and insulin signaling. These cell lines have been meticulously developed to exhibit a complete knockout of the KLF11 gene, allowing researchers to investigate the gene’s functions and the consequent biological impacts of its absence in a controlled environment.

The key mechanism behind KLF11 Gene Knockout Cell Lines involves CRISPR-Cas9 technology, which precisely creates targeted mutations in the KLF11 gene, resulting in a loss of function. This enables scientists to observe the downstream effects of KLF11 deletion on cellular pathways, gene expression, and metabolic regulation. By using these knockout models, researchers can effectively elucidate KLF11's involvement in diabetes, obesity, and other metabolic disorders, facilitating the discovery of novel therapeutic targets and strategies.

The scientific importance of these cell lines extends to both fundamental research and clinical applications. They provide invaluable insights for studying the pathophysiology of metabolic diseases and for developing potential interventions, making them a critical tool for translational research. Compared to traditional methods of gene knockdown, such as RNA interference, KLF11 Gene Knockout Cell Lines offer a more permanent solution for gene disruption, enabling more comprehensive and reproducible studies.

Moreover, the unique selling points of our KLF11 Gene Knockout Cell Lines include their reliability, reproducibility, and the ease of use in a wide range of experimental conditions. Researchers can trust these cell lines to provide consistent results that can be directly linked to the role of KLF11, thus enhancing the quality of their experimental outcomes. These models are essential for those looking to deepen their understanding of gene function in the context of metabolic disorders and develop innovative therapeutic approaches.

Our company prides itself on its commitment to advancing biological research by providing high-quality cellular models that meet rigorous scientific standards. With extensive expertise in genetic engineering and cell line development, we ensure that our products empower researchers and clinicians in their quest to unlock the complexities of gene function and its implications in health and disease.

Please note that all services are for research use only. Not intended for any clinical use.

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