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KLB Knockout Cell Lines

Gene: KLB

Official Full Name: klotho betaprovided by HGNC

Gene Summary: Enables fibroblast growth factor binding activity and fibroblast growth factor receptor binding activity. Predicted to be involved in carbohydrate metabolic process. Predicted to act upstream of or within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway and positive regulation of cell population proliferation. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01997 KLB Knockout cell line (A549) Human KLB 1:3~1:4 Negative Online Inquiry

Background

KLB Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to facilitate the study of the KLB gene's function and its associated pathways. These cell lines are created through advanced CRISPR-Cas9 technology, allowing for the precise deletion of the KLB gene, which encodes for Klotho beta—a protein implicated in a variety of biological processes including metabolism, aging, and disease progression.

The primary function of KLB Gene Knockout Cell Lines lies in their ability to serve as invaluable tools for researchers exploring the physiological and pathological roles of KLB. By removing the gene of interest, investigators can observe the resultant phenotypic changes, elucidating the gene’s impacts on signaling pathways, metabolic processes, and cellular responses. This knockout strategy provides a straightforward method to delineate KLB’s contributions to disease states, particularly in areas like obesity, cardiovascular health, and neurodegeneration.

The scientific importance of these cell lines cannot be overstated. They represent an essential resource in both foundational research and translational studies, enabling scientists to develop and test novel therapeutic strategies that target the KLB pathway. Their application extends to drug discovery, toxicity studies, and genetic studies, making them a pivotal asset for academic, pharmaceutical, and biotechnology sectors.

What sets KLB Gene Knockout Cell Lines apart from traditional cell models is their high specificity and reproducibility. These cell lines offer consistent performance and data integrity, significantly enhancing the reliability of research outcomes compared to non-targeted models or transient gene knockouts. Additionally, the availability of these knockout models shortens experimental timelines and expedites the research process by providing ready-to-use systems for hypothesis testing.

For researchers and clinicians, the value of KLB Gene Knockout Cell Lines lies in their capacity to provide deeper insights into KLB biology and its implications in health and disease. They equip scientists with the tools necessary to pave the way for breakthroughs in therapeutic interventions and personalized medicine.

As a company at the forefront of biotechnology innovation, we specialize in providing high-quality, genetically engineered cell lines that meet rigorous performance standards. Our commitment to excellence and scientific integrity ensures that we empower researchers with the resources they need to advance their critical work in understanding gene function and developing targeted therapies.

Please note that all services are for research use only. Not intended for any clinical use.

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