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KDELR1 Knockout Cell Lines

Gene: KDELR1

Official Full Name: KDEL endoplasmic reticulum protein retention receptor 1provided by HGNC

Gene Summary: Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31382 KDELR1 Knockout cell line (HeLa) Human KDELR1 1:3~1:6 Negative Online Inquiry
KO31383 KDELR1 Knockout cell line (HCT 116) Human KDELR1 1:2~1:4 Negative Online Inquiry
KO31384 KDELR1 Knockout cell line (HEK293) Human KDELR1 1:3~1:6 Negative Online Inquiry
KO31385 KDELR1 Knockout cell line (A549) Human KDELR1 1:3~1:4 Negative Online Inquiry

Background

KDELR1 Gene Knockout Cell Lines represent a cutting-edge biological product designed for researchers investigating the role of the KDEL receptor in cellular processes. By utilizing advanced CRISPR-Cas9 gene editing technology, these cell lines enable precise deletion of the KDELR1 gene, allowing for the in-depth study of its mechanisms in protein trafficking, stress responses, and cellular homeostasis.

The key function of KDELR1 is its involvement in retrieving proteins from the endoplasmic reticulum (ER) back to the Golgi apparatus, a crucial step in maintaining protein quality control within the cell. By knocking out KDELR1, researchers can explore how disruptions in this pathway affect cellular function, protein accumulation, and overall stress response mechanisms. This product serves as a vital tool in elucidating the pathophysiology of diseases linked to protein misfolding and ER stress, such as neurodegenerative disorders and certain cancers.

The scientific importance of KDELR1 Gene Knockout Cell Lines lies in their application across various research fields, including cell biology, molecular genetics, and therapeutic development. These knockout models provide a platform for testing hypotheses regarding the impact of KDELR1 on cellular processes, enabling researchers to pave the way for new therapeutic strategies and interventions.

What sets KDELR1 Gene Knockout Cell Lines apart from alternatives is their high specificity and efficiency in gene editing, coupled with robust validation through sequencing and functional assays. Whereas traditional approaches often yield variable results, these lines ensure consistent and reproducible outcomes, ultimately saving researchers valuable time and resources.

Researchers and clinicians benefit greatly from using these unique cell lines, as they offer a clear path to understanding the complexities of protein dynamics in health and disease. By generating insights into the KDELR1 function and its broader implications, scientists can drive innovative research forward and contribute to the development of targeted therapies.

Our company stands at the forefront of the biotechnology sector, actively providing high-quality genetic tools that empower scientific inquiry. With a team of experienced experts and a commitment to excellence, we ensure that our products not only meet but exceed the expectations of researchers, ultimately advancing the field of biological research and therapeutic applications.

Please note that all services are for research use only. Not intended for any clinical use.

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