Home / KAT6A Knockout Cell Lines

KAT6A Knockout Cell Lines

Gene: KAT6A

Official Full Name: lysine acetyltransferase 6Aprovided by HGNC

Gene Summary: This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain. It is part of a complex that acetylates lysine-9 residues in histone 3, and in addition, it acts as a co-activator for several transcription factors. Allelic variants of this gene are associated with an autosomal dominant form of cognitive disability. Chromosomal translocations of this gene are associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO09342 KAT6A Knockout cell line (HeLa) Human KAT6A 1:3~1:6 Negative Online Inquiry
KO09343 KAT6A Knockout cell line (HCT 116) Human KAT6A 1:2~1:4 Negative Online Inquiry
KO09344 KAT6A Knockout cell line (HEK293) Human KAT6A 1:3~1:6 Negative Online Inquiry
KO09345 KAT6A Knockout cell line (A549) Human KAT6A 1:3~1:4 Negative Online Inquiry

Background

KAT6A Gene Knockout Cell Lines are genetically engineered cell lines in which the KAT6A gene has been functionally disrupted, allowing researchers to study the gene's role in various biological processes. KAT6A encodes a lysine acetyltransferase involved in critical cellular processes, including gene expression regulation, cell cycle progression, and differentiation. The knockout of this gene facilitates the exploration of its involvement in pathologies such as cancer and developmental disorders.

The mechanism underlying KAT6A knockout is achieved through state-of-the-art CRISPR-Cas9 gene editing technology, which introduces specific mutations leading to gene inactivation. This precise alteration enables the investigation of KAT6A's functional contributions in cellular pathways, thereby enhancing the understanding of its role in oncogenesis and other diseases. Through the utilization of these cell lines, researchers can perform phenotypic analyses, drug response evaluations, and biomarker identification, ultimately fostering the development of targeted therapies.

The scientific importance of KAT6A Gene Knockout Cell Lines cannot be overstated; they represent a vital tool for elucidating the biological significance of KAT6A in both basic and translational research. Compared to conventional knockout models, these cell lines provide a more controlled environment, ensuring reproducibility and reliability in experimental setups. Furthermore, they save valuable time and resources, allowing for quicker insights and facilitating high-throughput screening applications.

The unique selling points of our KAT6A Gene Knockout Cell Lines lie in their high efficiency, robust performance, and ease of use. They are validated for specificity and exhibit consistent performance in diverse experimental conditions, making them suitable for various research applications. Researchers and clinicians alike will find these cell lines invaluable for advancing their work, particularly in areas focusing on cancer biology and genetic disorders.

Our company specializes in providing high-quality biological products that empower the life sciences community. With extensive expertise in genetic engineering and cell line development, we are committed to delivering innovative solutions that drive research breakthroughs and improve outcomes in a fast-evolving scientific landscape.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.