Home / ITIH4 Knockout Cell Lines

ITIH4 Knockout Cell Lines

Gene: ITIH4

Official Full Name: inter-alpha-trypsin inhibitor heavy chain 4provided by HGNC

Gene Summary: The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06431 ITIH4 Knockout cell line (HCT 116) Human ITIH4 1:2~1:4 Negative Online Inquiry

Background

ITIH4 Gene Knockout Cell Lines are specialized cell culture systems in which the ITIH4 gene has been precisely disrupted or deleted. This innovative product serves as a powerful tool for researchers investigating the biological roles of the ITIH4 gene, which encodes inter-alpha-trypsin inhibitor heavy chains—a component that plays a vital role in the regulation of extracellular matrix (ECM) components and inflammatory processes. By utilizing these knockout cell lines, scientists can elucidate the function of ITIH4 in various physiological and pathological contexts.

The fundamental mechanism underlying these cell lines involves targeted gene editing technologies, such as CRISPR-Cas9, which facilitate the precise alteration of the ITIH4 locus. As a result, these cell lines allow for the study of cellular behavior, signaling pathways, and phenotypic changes in the absence of ITIH4. They are instrumental in research areas such as cancer biology, wound healing, and inflammatory diseases, where the regulation of the ECM is crucial.

The scientific importance of ITIH4 Gene Knockout Cell Lines extends to both basic and translational research applications. In preclinical studies, these cell lines can be employed to assess the effects of potential therapeutic compounds targeting the ITIH4 pathway. Furthermore, their ability to model disease states accurately aids in the identification of biomarkers and therapeutic targets, vastly enhancing our understanding of disease mechanisms.

What sets our ITIH4 Gene Knockout Cell Lines apart from alternative products is their robust validation and performance reliability. Each cell line is rigorously tested for gene knockout efficacy and consistent growth patterns, ensuring that researchers can achieve reproducible results. Additionally, our extensive support and detailed technical documentation empower users to maximize the utility of these cell lines in their research endeavors.

For researchers and clinicians aiming to delve deeper into the complex biological roles of the ITIH4 gene, our ITIH4 Gene Knockout Cell Lines represent an invaluable asset. By providing the means to explore the multifaceted interactions within the ECM and their implications in disease, this product is poised to contribute significantly to the advancement of biomedical knowledge.

As a company dedicated to offering high-quality biological products, we pride ourselves on our expertise in gene editing technologies and cell line development. This commitment ensures that our customers receive not only superior products but also the support necessary to advance their research initiatives effectively.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.