Gene: ITGB6
Official Full Name: integrin subunit beta 6provided by HGNC
Gene Summary: This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms a dimer with an alpha v chain and this heterodimer can bind to ligands like fibronectin and transforming growth factor beta 1. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10279 | ITGB6 Knockout cell line (A549) | Human | ITGB6 | 1:3~1:4 | Negative | Online Inquiry |
ITGB6 Gene Knockout Cell Lines are meticulously engineered cell lines designed to abrogate the expression of the integrin beta-6 subunit (ITGB6), a crucial component in various cellular processes, including adhesion, migration, and signaling pathways in cancer biology and tissue homeostasis. The knockout of this gene enables researchers to elucidate the specific roles of ITGB6 in pathological and physiological contexts, making these cell lines an invaluable tool in the study of disease mechanisms.
By employing CRISPR-Cas9 gene-editing technology, ITGB6 Gene Knockout Cell Lines exhibit a complete disruption of the ITGB6 gene, leading to the functional ablation of integrin-dependent signaling pathways. This knockdown allows researchers to investigate the implications of ITGB6 in cellular dynamics, including cancer metastasis, immune response modulation, and tissue repair mechanisms. Their application extends across various research domains, from oncology to developmental biology, providing insight into the influence of integrins in cellular microenvironments.
The significance of ITGB6 Gene Knockout Cell Lines lies in their ability to uncover fundamental biological processes and potential therapeutic targets. Researchers can leverage these cell lines to identify alternative adhesion mechanisms in integrin-related pathways or explore the interactions between cancer cells and the extracellular matrix in greater detail. Compared to traditional knockout methods, which can be labor-intensive and time-consuming, our ITGB6 Gene Knockout Cell Lines offer a streamlined alternative, providing a reliable and reproducible model for experimentation.
What sets our ITGB6 Gene Knockout Cell Lines apart is their robust performance and high degree of specificity. They have been rigorously validated for the absence of ITGB6 expression and the functional consequences thereof, ensuring that users receive consistent results that are reflective of the genetic modifications.
Investing in ITGB6 Gene Knockout Cell Lines empowers researchers and clinicians to unlock new avenues of investigation, ultimately advancing our understanding of integrin biology and its implications in health and disease. Supported by our company’s deep expertise in genetic engineering and commitment to high-quality products, we provide a comprehensive array of biological tools designed to accelerate innovation and enhance scientific discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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