Gene: IRF1
Official Full Name: interferon regulatory factor 1provided by HGNC
Gene Summary: The protein encoded by this gene is a transcriptional regulator and tumor suppressor, serving as an activator of genes involved in both innate and acquired immune responses. The encoded protein activates the transcription of genes involved in the body's response to viruses and bacteria, playing a role in cell proliferation, apoptosis, the immune response, and DNA damage response. This protein represses the transcription of several other genes. As a tumor suppressor, it both suppresses tumor cell growth and stimulates an immune response against tumor cells. Defects in this gene have been associated with gastric cancer, myelogenous leukemia, and lung cancer. [provided by RefSeq, Aug 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08306 | IRF1 Knockout cell line (HeLa) | Human | IRF1 | 1:3~1:6 | Negative | Online Inquiry |
KO08307 | IRF1 Knockout cell line (HCT 116) | Human | IRF1 | 1:2~1:4 | Negative | Online Inquiry |
KO08308 | IRF1 Knockout cell line (HEK293) | Human | IRF1 | 1:3~1:6 | Negative | Online Inquiry |
KO08309 | IRF1 Knockout cell line (A549) | Human | IRF1 | 1:3~1:4 | Negative | Online Inquiry |
IRF1 Gene Knockout Cell Lines are specially engineered cell lines that feature a targeted disruption of the Interferon Regulatory Factor 1 (IRF1) gene. This critical alteration allows for the exploration of the IRF1 gene's role in immune responses, apoptosis, and cellular signaling pathways. By utilizing CRISPR-Cas9 or other gene-editing techniques, these cell lines provide researchers with a powerful tool to investigate the functional implications of IRF1 deficiency in various biological contexts.
The key mechanism of IRF1 Gene Knockout Cell Lines lies in their ability to mimic conditions with reduced or absent IRF1 activity, enabling researchers to delineate the gene's specific contributions to cellular behavior and immune responses. These knockout lines facilitate studies on the modulation of genes regulated by IRF1, thus elucidating its role in host defense mechanisms and its involvement in oncogenesis and inflammatory diseases.
In research settings, these cell lines are invaluable for deciphering complex immunological responses, testing drug effects, and studying gene interactions in cancer biology. Clinically, they hold promise for identifying new therapeutic targets by unraveling the pathways associated with IRF1, which could lead to novel strategies for treating diseases linked to immune dysfunction or tumorigenesis.
What sets our IRF1 Gene Knockout Cell Lines apart from alternatives is their high editing efficiency, genetic stability, and robust performance in various assays. These features ensure reliable reproducibility of results while minimizing the time and resources required for experimentation.
For researchers and clinicians alike, these cell lines provide unparalleled opportunities to advance our understanding of critical transcriptional regulatory networks, making them a vital addition to any molecular biology toolkit. Our company's commitment to excellence and innovation in producing genetically engineered models reflects our expertise in supporting cutting-edge research and fostering scientific discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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