Gene: INPPL1
Official Full Name: inositol polyphosphate phosphatase like 1provided by HGNC
Gene Summary: The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO07899 | INPPL1 Knockout cell line (HeLa) | Human | INPPL1 | 1:3~1:6 | Negative | Online Inquiry |
KO07900 | INPPL1 Knockout cell line (HCT 116) | Human | INPPL1 | 1:2~1:4 | Negative | Online Inquiry |
KO07901 | INPPL1 Knockout cell line (HEK293) | Human | INPPL1 | 1:3~1:6 | Negative | Online Inquiry |
KO07902 | INPPL1 Knockout cell line (A549) | Human | INPPL1 | 1:3~1:4 | Negative | Online Inquiry |
INPPL1 Gene Knockout Cell Lines represent a specialized set of genetically engineered cellular models designed for the in-depth study of the INPPL1 gene, which plays a critical role in various cellular processes, including signal transduction and phosphoinositide metabolism. These knockout cell lines have been meticulously crafted using CRISPR-Cas9 technology to achieve precise gene disruption, allowing researchers to elucidate the biochemical and physiological impacts of loss-of-function mutations associated with INPPL1.
Key functions of the INPPL1 knockout cell lines include the ability to investigate alterations in cellular signaling pathways, receptor activity, and metabolic responses. By eliminating the INPPL1 gene, scientists can employ these models to assess how this gene influences important processes like insulin signaling, cell growth, and apoptosis. The knockout approach provides a foundational platform for exploring both the basic science of gene function and the pathophysiology of diseases linked to INPPL1 dysregulation, including metabolic disorders and cancer.
The scientific importance of INPPL1 knockout cell lines extends to various applications in both research and clinical settings. These cell lines facilitate targeted drug discovery, allowing for the identification of novel therapeutic targets, and provide insights into the mechanisms underlying genetic disorders. Researchers can utilize these lines to screen for pharmacological agents that may overcome the functional deficits caused by INPPL1 loss.
Compared to conventional wild-type cell lines, the INPPL1 knockout models offer significant advantages. They present a unique platform for hypothesis testing and mechanistic studies that would otherwise be challenging in typical cellular environments with normal gene expression. This specificity enhances the reproducibility and relevance of experimental results, providing a clearer understanding of the role of INPPL1 in health and disease.
For researchers and clinicians, the INPPL1 Gene Knockout Cell Lines are an invaluable tool, enabling advanced studies that can contribute to breakthroughs in therapeutic discovery and precision medicine. Our company's expertise in genetic engineering and commitment to providing high-quality, reliable biological resources ensure that users have access to the best tools available for their groundbreaking research.
Please note that all services are for research use only. Not intended for any clinical use.
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