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ILK Knockout Cell Lines

Gene: ILK

Official Full Name: integrin linked kinaseprovided by HGNC

Gene Summary: This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37056 ILK Knockout cell line (HeLa) Human ILK 1:3~1:6 Negative Online Inquiry
KO37057 ILK Knockout cell line (HCT 116) Human ILK 1:2~1:4 Negative Online Inquiry
KO37058 ILK Knockout cell line (HEK293) Human ILK 1:3~1:6 Negative Online Inquiry
KO37059 ILK Knockout cell line (A549) Human ILK 1:3~1:4 Negative Online Inquiry

Background

ILK Gene Knockout Cell Lines are meticulously engineered cellular models designed to facilitate the study of Integrin-linked Kinase (ILK) and its role in various biological processes. By utilizing CRISPR-Cas9 technology, these cell lines exhibit a precise knockout of the ILK gene, allowing for the investigation of its specific functions in signaling pathways, cell adhesion, and migration. This targeted gene disruption not only enables researchers to dissect the molecular mechanisms governing ILK activity but also provides a valuable tool for elucidating its contributions to cancer progression, cardiovascular diseases, and other disorders.

The primary mechanism of these knockout cell lines involves the introduction of double-strand breaks in the ILK gene, leading to a high frequency of insertion/deletion mutations during the DNA repair process. Consequently, this results in a functional disruption of ILK protein expression. The ability to study ILK in a controlled environment enhances the reproducibility and reliability of experimental results, allowing scientists to draw accurate conclusions regarding the kinase's biological relevance.

In both research and clinical settings, ILK Gene Knockout Cell Lines stand out due to their broad applicability in drug discovery and development, enabling high-throughput screening of potential therapeutic agents targeting ILK-related pathways. Their use can uncover novel biomarkers and therapeutic targets, thereby advancing personalized medicine approaches.

What differentiates our ILK Gene Knockout Cell Lines from alternatives is the verified specificity and efficiency of gene knockout, combined with comprehensive protocols to ensure consistent performance. Additionally, our commitment to high-quality cell line validation ensures minimal variability, promoting confidence in experimental outcomes.

For researchers and clinicians invested in cellular signaling studies, the ILK Gene Knockout Cell Lines provide invaluable insights that can advance our understanding of complex disease mechanisms. They represent a critical resource for innovative therapeutic exploration, transforming the landscape of predictive biology.

Our company prides itself on its cutting-edge technologies and a deep commitment to supporting the scientific community with reliable and effective biological products. With our extensive expertise in gene editing and cellular biology, we are dedicated to accelerating research and improving therapeutic strategies in the field.

Please note that all services are for research use only. Not intended for any clinical use.

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