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ICE1 Knockout Cell Lines

Gene: ICE1

Official Full Name: interactor of little elongation complex ELL subunit 1provided by HGNC

Gene Summary: Enables protein-macromolecule adaptor activity. Involved in several processes, including positive regulation of intracellular protein transport; positive regulation of transcription by RNA polymerase III; and snRNA transcription. Located in Cajal body; euchromatin; and histone locus body. Part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29357 ICE1 Knockout cell line (HeLa) Human ICE1 1:3~1:6 Negative Online Inquiry
KO29358 ICE1 Knockout cell line (HCT 116) Human ICE1 1:2~1:4 Negative Online Inquiry
KO29359 ICE1 Knockout cell line (HEK293) Human ICE1 1:3~1:6 Negative Online Inquiry
KO29360 ICE1 Knockout cell line (A549) Human ICE1 1:3~1:4 Negative Online Inquiry

Background

ICE1 Gene Knockout Cell Lines are specialized cellular models that have been genetically engineered to lack the expression of the ICE1 gene, a critical component involved in various cellular processes, including stress response and transcription regulation. These knockout cell lines serve as invaluable tools for researchers seeking to elucidate the role of ICE1 in cellular function and disease mechanisms. By removing the ICE1 gene, these cell lines provide a controlled environment to study gene interactions and pathways associated with cellular stress responses, inflammation, and development.

The primary function of ICE1 knockout cell lines is to enable researchers to observe the effects of ICE1 loss on cellular behavior, such as differentiation, proliferation, and response to external stimuli. The underlying mechanism involves the disruption of transcriptional regulation pathways influenced by ICE1, thereby allowing scientists to investigate compensatory mechanisms and alternative pathways that may activate in response to ICE1 absence. This makes ICE1 knockout cell lines particularly compelling for studying diseases where ICE1 is implicated, offering insights into potential therapeutic targets.

In terms of scientific importance, ICE1 knockout cell lines can be critically applied in both basic and applied research, including pharmacological studies and gene therapy. Their utility in high-throughput screening for drug discovery further enhances their value in advancing personalized medicine approaches.

What sets ICE1 Gene Knockout Cell Lines apart from alternatives is their precise genetic modification, ensuring reproducibility and reliability in experimental outcomes. Additionally, the robustness of these cell lines allows them to be used across various platforms and conditions, making them suitable for a wide array of applications.

Researchers and clinicians will find these knockout cell lines invaluable for discovering new biological insights and translational research. The ability to manipulate and study specific genes correlates directly with the advancement of innovative treatments and therapies, addressing health challenges more effectively.

Our company is renowned for its expertise in cellular and molecular biology, providing high-quality biological products that meet the evolving needs of the scientific community. With a commitment to innovation and excellence, we are proud to contribute to cutting-edge research and development through our ICE1 Gene Knockout Cell Lines.

Please note that all services are for research use only. Not intended for any clinical use.

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