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ICA1 Knockout Cell Lines

Gene: ICA1

Official Full Name: islet cell autoantigen 1provided by HGNC

Gene Summary: This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37136 ICA1 Knockout cell line (HeLa) Human ICA1 1:3~1:6 Negative Online Inquiry
KO37137 ICA1 Knockout cell line (HCT 116) Human ICA1 1:2~1:4 Negative Online Inquiry
KO37138 ICA1 Knockout cell line (HEK293) Human ICA1 1:3~1:6 Negative Online Inquiry

Background

ICA1 Gene Knockout Cell Lines are specialized biological tools designed for studying the intracellular dynamics associated with the ICA1 gene, which is known to play a critical role in neuroendocrine secretion and neuronal function. These cell lines are developed using advanced CRISPR/Cas9 gene editing technology, enabling targeted disruption of the ICA1 gene. This knockout model allows researchers to probe into the gene's physiological roles and the molecular pathways it influences, facilitating a deeper understanding of neurodegenerative diseases and endocrine disorders.

The primary function of ICA1 Gene Knockout Cell Lines is to serve as an invaluable platform for in vitro experiments aimed at elucidating the cellular mechanisms of ICA1 gene regulation. By examining these knockout cell lines, scientists can investigate the effects on neurotransmitter release, cell signaling pathways, and other cellular activities that are pivotal to neuronal health and function. The precise genetic alteration provided by these cell lines enhances reproducibility and accuracy in research outcomes, making them an essential resource for both academic and clinical laboratories.

From a scientific perspective, these knockout cell lines have garnered significant attention in neurobiology and endocrinology research. They enable exquisite dissection of the molecular frameworks underpinning various disorders, including neurodegeneration and hormone dysregulation, thereby contributing to the development of novel therapeutic strategies. Additionally, these cell lines offer a robust system for drug screening and personalized medicine approaches, allowing clinicians and researchers to identify candidate molecules with therapeutic potential.

One of the key advantages of ICA1 Gene Knockout Cell Lines is their specificity and reliability compared to alternative models. Unlike traditional transgenic models, these knockout cell lines are quicker to generate, more cost-effective, and provide a high degree of control over genetic expression. Their ease of use allows for streamlined experimental workflows, saving time and resources while increasing throughput.

For researchers and clinicians looking for cutting-edge models to support their investigations, ICA1 Gene Knockout Cell Lines stand out as a critical asset. Their utility in exploring root causes of disease and potential therapies makes them an indispensable part of modern biological research. Our company specializes in advanced cellular models and gene-editing technologies, providing scientists with high-quality products that empower innovative research and ultimately contribute to significant advancements in health science.

Please note that all services are for research use only. Not intended for any clinical use.

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