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HSPH1 Knockout Cell Lines

Gene: HSPH1

Official Full Name: heat shock protein family H (Hsp110) member 1provided by HGNC

Gene Summary: This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers. [provided by RefSeq, Mar 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31488 HSPH1 Knockout cell line (HeLa) Human HSPH1 1:3~1:6 Negative Online Inquiry
KO31489 HSPH1 Knockout cell line (HCT 116) Human HSPH1 1:2~1:4 Negative Online Inquiry
KO31490 HSPH1 Knockout cell line (HEK293) Human HSPH1 1:3~1:6 Negative Online Inquiry
KO31491 HSPH1 Knockout cell line (A549) Human HSPH1 1:3~1:4 Negative Online Inquiry

Background

HSPH1 Gene Knockout Cell Lines are specialized cell lines in which the HSPH1 gene, also known as Heat Shock Protein H1, has been systematically disrupted through precise genetic engineering techniques. This product enables researchers to investigate the physiological and pathological roles of HSPH1, a gene implicated in cellular stress responses and various diseases, including cancer and neurodegenerative disorders. By using these knockout cell lines, scientists can elucidate the mechanisms by which HSPH1 contributes to cellular homeostasis, stress tolerance, and disease progression.

The key function of HSPH1 involves its role in protein folding and protection against aggregation, particularly under stress conditions such as heat shock or oxidative stress. Knocking out this gene allows researchers to study the consequent effects on protein homeostasis, cellular viability, and response to stressors. This facilitates a deeper understanding of the molecular mechanisms underlying cellular functions and pathophysiology.

In both research and clinical settings, the importance of HSPH1 Gene Knockout Cell Lines extends to drug discovery, biomarker identification, and the development of novel therapies targeting stress response pathways. By providing a controlled system to study the absence of HSPH1, researchers can better understand how its modulation affects cell behavior, providing insights into potential therapeutic interventions.

Compared to traditional cell line models, HSPH1 knockout cell lines offer a unique advantage by allowing for direct observation of the absence of this protein's influence on various cellular processes. This specificity is critical for developing targeted therapies that can modulate stress responses in diseases where HSPH1 is dysregulated.

For researchers and clinicians seeking to unravel the complexities of cellular stress responses and their implications in disease, HSPH1 Gene Knockout Cell Lines offer a valuable tool that bridges basic research and clinical applications. Our company prides itself on providing high-quality, genetically characterized cell lines that empower the scientific community to push the boundaries of discovery and therapeutic advancements in cellular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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