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HSPA12B Knockout Cell Lines

Gene: HSPA12B

Official Full Name: heat shock protein family A (Hsp70) member 12Bprovided by HGNC

Gene Summary: The protein encoded by this gene contains an atypical heat shock protein 70 (Hsp70) ATPase domain and is therefore a distant member of the mammalian Hsp70 family. This gene may be involved in susceptibility to atherosclerosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30496 HSPA12B Knockout cell line (HCT 116) Human HSPA12B 1:2~1:4 Negative Online Inquiry
KO30497 HSPA12B Knockout cell line (A549) Human HSPA12B 1:3~1:4 Negative Online Inquiry

Background

HSPA12B Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the expression of the HSPA12B gene, which encodes heat shock protein 70 (Hsp70). This product serves as a powerful tool for researchers studying the role of HSPA12B in cellular stress responses, protein homeostasis, and various disease mechanisms related to cancer, neurodegeneration, and metabolic disorders. The elimination of HSPA12B expression allows for the direct observation of the gene's functional consequences, enabling researchers to elucidate its contributions to cellular physiology and pathology.

These knockout cell lines operate on the principle of gene editing through CRISPR/Cas9 technology, providing a precise and efficient method for generating mutations in the HSPA12B locus. Researchers can utilize these lines to investigate the impact of HSPA12B loss on cellular processes such as apoptosis, proliferation, and response to environmental stressors. Additionally, the knockout model can facilitate drug testing and biomarker discovery, advancing both fundamental biological understanding and therapeutic development.

The scientific importance of HSPA12B Gene Knockout Cell Lines lies in their broad applicability in medical research, particularly in elucidating therapeutic targets for conditions where Hsp70 has been implicated. Compared to conventional cell lines or less targeted genetic modification techniques, these knockout lines offer unparalleled specificity and reliability in gene manipulation, reducing background interference and enhancing experimental clarity.

For researchers and clinicians, the unique selling points of HSPA12B Gene Knockout Cell Lines include their customizable nature and the robust validation of gene disruption, which ensures reproducibility in experimental setups. Furthermore, these cell lines open pathways to innovative research discoveries and are essential in the pursuit of novel interventions in health and disease.

Our company specializes in high-quality biological products developed through cutting-edge techniques and backed by extensive expertise in genetic engineering. We are committed to empowering researchers and clinicians with the tools they need for groundbreaking discoveries in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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