Gene: HSD17B4
Official Full Name: hydroxysteroid 17-beta dehydrogenase 4provided by HGNC
Gene Summary: The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37184 | HSD17B4 Knockout cell line (HeLa) | Human | HSD17B4 | 1:3~1:6 | Negative | Online Inquiry |
KO37185 | HSD17B4 Knockout cell line (HCT 116) | Human | HSD17B4 | 1:2~1:4 | Negative | Online Inquiry |
KO37186 | HSD17B4 Knockout cell line (HEK293) | Human | HSD17B4 | 1:3~1:6 | Negative | Online Inquiry |
KO37187 | HSD17B4 Knockout cell line (A549) | Human | HSD17B4 | 1:3~1:4 | Negative | Online Inquiry |
HSD17B4 Gene Knockout Cell Lines are specialized cellular models that undergo targeted disruption of the HSD17B4 gene, which encodes an enzyme critically involved in steroid metabolism and signaling pathways. By utilizing advanced gene-editing techniques, these cell lines serve as invaluable tools for unraveling the complexities of steroidogenesis and related metabolic processes.
The primary function of HSD17B4 is to facilitate the conversion of various steroid hormones, impacting vital physiological processes such as reproductive health and hormonal regulation. The knockout of this gene allows researchers to observe the resultant biochemical and physiological responses in a controlled environment, providing insights into the gene's role in cellular function and pathophysiology. Mechanistically, the absence of HSD17B4 leads to altered steroid hormone levels, enabling the study of downstream signaling pathways and their implications in diseases such as hormone-dependent cancers and metabolic disorders.
The scientific importance of HSD17B4 Gene Knockout Cell Lines extends to both academic research and clinical applications. Researchers investigate the nuances of steroid hormone actions, potentially uncovering novel therapeutic targets for diverse health conditions. In clinical settings, understanding the implications of HSD17B4 could lead to improved diagnostic and treatment strategies for patients suffering from endocrine dysfunction.
Unique advantages of our HSD17B4 Gene Knockout Cell Lines include their high specificity and reproducibility compared to traditional knockout models, which may introduce off-target effects. Our product is meticulously validated to ensure consistent performance across a range of experiments, providing a reliable platform for exploration. Furthermore, the ease of use and compatibility with existing laboratory workflows make these cell lines a go-to choice for a multitude of research applications.
For researchers and clinicians focused on elucidating hormonal pathways and their physiological relevance, HSD17B4 Gene Knockout Cell Lines are an essential addition to their toolkit. With our commitment to scientific excellence and innovation, [Your Company Name] stands at the forefront of providing high-quality biological products engineered for impactful research outcomes, ensuring that our offerings meet the evolving needs of the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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