Gene: HS3ST3A1
Official Full Name: heparan sulfate-glucosamine 3-sulfotransferase 3A1provided by HGNC
Gene Summary: Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. The sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1, and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta. [provided by RefSeq, Dec 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32456 | HS3ST3A1 Knockout cell line (HEK293) | Human | HS3ST3A1 | 1:3~1:6 | Negative | Online Inquiry |
HS3ST3A1 Gene Knockout Cell Lines represent a specialized biological tool designed for advanced genetic research, particularly focusing on the role of the HS3ST3A1 gene in cellular processes. These engineered cell lines are created through targeted genome editing techniques, such as CRISPR-Cas9, to effectively disrupt the HS3ST3A1 gene, which encodes for an enzyme critical to the biosynthesis of heparan sulfate proteoglycans. By eliminating this gene, researchers can investigate the downstream effects on cellular signaling, proliferation, and differentiation, thus elucidating the gene's biological functions.
The primary mechanism at play involves the generation of haplosufficient or haploinsufficient models that mimic disease states, thereby serving as essential systems for examining gene function and regulation. In both basic and applied research, these cell lines facilitate studies related to cell-cell interactions, tumor biology, and developmental processes, making them invaluable for dissecting complex biological pathways.
From a scientific perspective, HS3ST3A1 Gene Knockout Cell Lines hold significant importance in research settings, particularly for their applications in cancer research and regenerative medicine. They provide researchers with the capability to create more physiologically relevant models compared to traditional methods, contributing to a more nuanced understanding of cellular dynamics in disease states and potential therapeutic interventions.
Unique advantages of HS3ST3A1 Gene Knockout Cell Lines over alternative models include their specificity in gene targeting, high efficiency in knockouts, and the consistency they provide across experiments, which are essential for reproducibility. These attributes make them a preferred choice for researchers seeking reliable models for high-throughput screening and functional assays.
The potential to elucidate the pathophysiological roles of HS3ST3A1 offers invaluable insights not only for researchers but also for clinicians aiming to translate findings into therapeutic applications. As such, these cell lines present a compelling opportunity for advancing medical research and improving patient outcomes.
Our company specializes in providing advanced molecular tools and custom cellular models, backed by a team of experts who are dedicated to supporting the scientific community's pursuit of groundbreaking discoveries. With HS3ST3A1 Gene Knockout Cell Lines, we empower researchers to push the boundaries of knowledge in cellular and molecular biology.
Please note that all services are for research use only. Not intended for any clinical use.
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