Gene: HR
Official Full Name: HR lysine demethylase and nuclear receptor corepressorprovided by HGNC
Gene Summary: This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by a regulatory open reading frame (ORF) that exists upstream of the primary ORF. Mutations in this upstream ORF cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37196 | HR Knockout cell line (HeLa) | Human | HR | 1:3~1:6 | Negative | Online Inquiry |
KO37197 | HR Knockout cell line (HCT 116) | Human | HR | 1:2~1:4 | Negative | Online Inquiry |
KO37198 | HR Knockout cell line (A549) | Human | HR | 1:3~1:4 | Negative | Online Inquiry |
HR Gene Knockout Cell Lines represent a breakthrough in genetic research and biotechnology, providing a powerful tool for studying gene function through precise genetic modification. These cell lines are engineered to have specific genes inactivated or "knocked out," enabling researchers to investigate the role of individual genes in cellular processes and disease mechanisms.
The key function of HR Gene Knockout Cell Lines lies in their ability to elucidate gene function and regulation. Using advanced techniques such as CRISPR-Cas9 gene editing, these cell lines are created with high specificity, ensuring that the targeted gene is effectively disrupted while minimizing off-target effects. This precision allows for the generation of isogenic cell lines that can be utilized for comparative studies, making it easier to understand the consequences of gene inactivation in various biological contexts.
The scientific significance of HR Gene Knockout Cell Lines is multifaceted, with applications spanning fundamental research, drug development, and cultivation of disease models. In clinical settings, they serve as invaluable models for studying genetic disorders, cancer biology, and responses to therapeutic interventions, facilitating the identification of novel drug targets and biomarkers.
What sets our HR Gene Knockout Cell Lines apart from competitors is their rigorously validated background and the ease of use in various experimental setups. Researchers benefit from our extensive support materials, including detailed protocols and data sheets that ensure reproducibility and reliability in experiments. Moreover, our commitment to using ethical and sustainable biosourcing practices enhances the ecological and ethical appeal of our products.
In a landscape where understanding gene function is crucial, HR Gene Knockout Cell Lines provide researchers, clinicians, and biopharmaceutical companies with an essential resource for advancing genetic studies and developing innovative therapeutic strategies. Our company's expertise in cellular engineering and commitment to quality signals our dedication to fostering scientific discovery and driving meaningful advancements in genetic research.
Please note that all services are for research use only. Not intended for any clinical use.
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