Gene: HOXD4
Official Full Name: homeobox D4provided by HGNC
Gene Summary: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in determining positional values in developing limb buds. Alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37227 | HOXD4 Knockout cell line (HEK293) | Human | HOXD4 | 1:3~1:6 | Negative | Online Inquiry |
HOXD4 Gene Knockout Cell Lines are genetically engineered cellular models designed to eliminate the expression of the HOXD4 gene, a member of the homeobox gene family known for its crucial role in developmental processes and gene regulation. These knockout cell lines facilitate the study of gene function by allowing researchers to observe the phenotypic consequences of HOXD4 loss, thereby elucidating the gene's involvement in key biological pathways and disease mechanisms.
The primary function of HOXD4 Gene Knockout Cell Lines is to provide a controlled environment in which the effects of HOXD4 deficiency can be systematically analyzed. The gene knockout is achieved through advanced gene-editing techniques, such as CRISPR-Cas9 or RNA interference, that specifically target and disrupt the HOXD4 gene, leading to its non-expression. This approach allows researchers to investigate cellular responses and alterations in gene expression profiles in the absence of HOXD4, which is vital for understanding its role in developmental biology and pathology.
Scientifically, these cell lines are significant tools in both basic research and clinical applications. They serve as vital platforms for studying developmental disorders, cancer, and other diseases where HOXD4 is implicated. The HOXD4 knockout models can aid in drug discovery by providing insights into potential therapeutic targets and enhancing the understanding of drug interactions with developmental processes.
What sets HOXD4 Gene Knockout Cell Lines apart from other genetic models is their high specificity and reproducibility. Researchers benefit from the precise nature of CRISPR technology, ensuring that the knockout is effective and that off-target effects are minimized. Additionally, these cell lines are optimized for consistent performance across various experimental conditions, offering researchers reliable data and reproducibility.
For researchers and clinicians, the value of HOXD4 Gene Knockout Cell Lines lies in their ability to streamline investigative workflows and accelerate the discovery of gene function and its implications in health and disease. These models open new avenues for research that may ultimately lead to better therapeutic strategies and interventions.
At our company, we pride ourselves on providing high-quality, customizable research tools, backed by our expertise in genetic engineering and cell line development. We are committed to advancing scientific knowledge and improving research outcomes through innovative biological products, making them accessible to the broader research community.
Please note that all services are for research use only. Not intended for any clinical use.
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