Gene: HOXD11
Official Full Name: homeobox D11provided by HGNC
Gene Summary: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in forelimb morphogenesis. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37218 | HOXD11 Knockout cell line (HEK293) | Human | HOXD11 | 1:3~1:6 | Negative | Online Inquiry |
KO37219 | HOXD11 Knockout cell line (A549) | Human | HOXD11 | 1:3~1:4 | Negative | Online Inquiry |
HOXD11 Gene Knockout Cell Lines are innovative biological tools specifically designed to study the functional role of the HOXD11 gene, which encodes a member of the homeobox family of transcription factors. This gene plays a crucial role in the regulation of developmental processes, particularly those involved in limb formation and morphogenesis. The HOXD11 Gene Knockout Cell Lines have been engineered using CRISPR-Cas9 technology to produce precise deletions of the HOXD11 gene, allowing researchers to investigate its biological significance through loss-of-function studies.
The primary function of these cell lines is to facilitate the elucidation of the downstream effects of HOXD11 gene ablation. By comparing the knockout cell lines with their wild-type counterparts, researchers can identify specific pathways and molecular interactions disrupted due to the absence of HOXD11, including those influencing embryonic development and potential implications for congenital disorders. Furthermore, these cell lines serve as vital models for drug testing and gene therapy approaches aimed at correcting or compensating for the effects of HOXD11 dysfunction.
The scientific importance of HOXD11 Gene Knockout Cell Lines is underscored by their vast applications in both research and clinical settings. They can be employed to advance our understanding of limb patterning, skeletal malformations, and other developmental abnormalities, making them a valuable asset for developmental biology studies. Additionally, the mechanisms revealed through these studies could lead to new therapeutic strategies for conditions linked to HOXD11 dysregulation.
When compared to conventional knockout models generated via traditional methods, our HOXD11 Gene Knockout Cell Lines offer several unique advantages. These include higher efficiency in gene editing, reduced off-target effects, and the ability to produce homogeneous, reproducible results, all of which enhance the reliability of experimental outcomes. Moreover, their ready-to-use nature streamlines experimental workflows, saving researchers valuable time and resources.
For researchers and clinicians, the value of HOXD11 Gene Knockout Cell Lines lies in their potential to unlock critical insights into gene function and regulation, ultimately contributing to advancements in regenerative medicine and therapeutic intervention strategies. Our company is dedicated to providing high-quality biological products backed by extensive expertise in molecular biology and genetics, ensuring that researchers have access to the tools they need to drive scientific innovation and discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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