Gene: HOXA1
Official Full Name: homeobox A1provided by HGNC
Gene Summary: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. Two transcript variants encoding two different isoforms have been found for this gene, with only one of the isoforms containing the homeodomain region. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37308 | HOXA1 Knockout cell line (HCT 116) | Human | HOXA1 | 1:2~1:4 | Negative | Online Inquiry |
KO37309 | HOXA1 Knockout cell line (HEK293) | Human | HOXA1 | 1:3~1:6 | Negative | Online Inquiry |
KO37310 | HOXA1 Knockout cell line (A549) | Human | HOXA1 | 1:3~1:4 | Negative | Online Inquiry |
The HOXA1 Gene Knockout Cell Lines are specifically engineered cellular models in which the HOXA1 gene has been disrupted through advanced genome-editing techniques, such as CRISPR-Cas9. These cell lines facilitate the investigation of the HOXA1 gene's role in various biological processes and its implications in developmental and pathological states. By generating precise knockouts, researchers can elucidate the gene's function and contributions to oncogenesis, neurodevelopmental disorders, and other significant health conditions.
The principle mechanism behind these knockout cell lines involves the targeted deletion of the HOXA1 gene, which is critical during embryonic development and is implicated in the regulation of downstream genes and signaling pathways. Inactivation of HOXA1 allows for the study of compensatory mechanisms and the effects of gene loss on cellular behavior, differentiation, and lineage specification. Researchers utilizing HOXA1 knockout models can gain insights into cellular processes such as apoptosis, proliferation, and migration, which are essential for understanding complex biological systems.
From a scientific perspective, these cell lines serve as invaluable tools in the research landscape. They can be employed in drug discovery and development, helping to identify potential therapeutic targets for diseases related to HOXA1 dysfunction. Moreover, these models have clinical relevancy, bridging the gap between basic research and potential clinical applications in regenerative medicine and gene therapy.
What sets HOXA1 Gene Knockout Cell Lines apart from alternative models is their precision and reproducibility. Developed under stringent quality controls, these cell lines provide uniformity in experimental conditions, minimizing variations that can skew results. The availability of these knockout lines also accelerates the pace of research, enabling teams to focus on their experiments without the need for extensive preliminary genetic modifications.
For researchers and clinicians, the HOXA1 Gene Knockout Cell Lines offer a resounding advantage in tackling HOXA1-related biological inquiries, facilitating significant findings that can lead to innovative therapeutics. Our company stands at the forefront of genetic engineering technologies, dedicated to providing top-tier biological products that empower the scientific community to explore and conquer the complexities of human health.
Please note that all services are for research use only. Not intended for any clinical use.
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