Gene: HEY2
Official Full Name: hes related family bHLH transcription factor with YRPW motif 2provided by HGNC
Gene Summary: This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO11397 | HEY2 Knockout cell line (HEK293) | Human | HEY2 | 1:3~1:6 | Negative | Online Inquiry |
HEY2 Gene Knockout Cell Lines are genetically engineered cellular models that provide researchers with an essential tool for studying the molecular mechanisms underlying various biological processes and disease states. These cell lines are created through precise gene editing techniques, specifically CRISPR/Cas9 technology, to disrupt the HEY2 gene, which is known to play a significant role in developmental pathways and oncogenic processes.
The key function of HEY2 gene knockout cell lines lies in their ability to facilitate detailed investigations into the gene's role in regulating cellular behavior, differentiation, and proliferation. By eliminating the HEY2 gene, these cell lines enable researchers to observe resulting phenotypic changes, providing insights into how this gene contributes to tissue regeneration and tumorigenesis. This knockout model is particularly valuable in studying cardiovascular diseases and cancer, where HEY2 is implicated.
In a scientific context, the importance of HEY2 gene knockout cell lines extends to both basic and applied research. They serve as a powerful platform for drug discovery, biomarker identification, and the development of therapeutic strategies targeting HEY2-related pathways. Their utility in preclinical studies allows researchers to assess the viability and efficacy of potential therapies in a controlled setting.
What sets our HEY2 gene knockout cell lines apart from other models is the high efficiency of gene editing achieved through our proprietary protocols that ensure minimal off-target effects and consistent cellular behavior across batches. This enhances reproducibility and reliability in experimental results, which is crucial for advancing scientific understanding.
For researchers and clinicians, these HEY2 knockout models present an invaluable resource for elucidating gene function and developing targeted interventions. Our commitment to quality and innovation in genetic engineering, alongside our expertise in cellular models, positions us as a trusted partner in advancing research and clinical applications. By choosing our HEY2 gene knockout cell lines, users can be confident in the integrity and efficacy of their experimental design, ultimately fostering breakthroughs in translational biology.
Please note that all services are for research use only. Not intended for any clinical use.
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