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HECTD4 Knockout Cell Lines

Gene: HECTD4

Official Full Name: HECT domain E3 ubiquitin protein ligase 4provided by HGNC

Gene Summary: Predicted to enable ubiquitin-protein transferase activity. Involved in glucose homeostasis and glucose metabolic process. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO17139 HECTD4 Knockout cell line (HeLa) Human HECTD4 1:3~1:6 Negative Online Inquiry
KO17140 HECTD4 Knockout cell line (HCT 116) Human HECTD4 1:2~1:4 Negative Online Inquiry
KO17141 HECTD4 Knockout cell line (HEK293) Human HECTD4 1:3~1:6 Negative Online Inquiry
KO17142 HECTD4 Knockout cell line (A549) Human HECTD4 1:3~1:4 Negative Online Inquiry

Background

HECTD4 Gene Knockout Cell Lines are advanced biological tools that facilitate the study of the HECTD4 gene, a crucial component in various cellular processes, including protein ubiquitination, cell cycle regulation, and signal transduction pathways. By disrupting the function of the HECTD4 gene, these cell lines provide researchers with an invaluable platform to investigate the gene's role in both normal physiology and disease mechanisms, including cancer and neurodegenerative disorders.

The HECTD4 gene is known to encode a E3 ubiquitin ligase, which plays a pivotal role in tagging proteins for degradation via the ubiquitin-proteasome pathway. The knockout of HECTD4 in these cell lines elicits alterations in protein stability and cellular signaling, allowing scientists to dissect the molecular pathways influenced by the loss of HECTD4 function. Moreover, the gene knockout leads to observable phenotypic changes, which further enhance the understanding of HECTD4's contribution to cellular homeostasis and pathology.

The scientific importance of HECTD4 Gene Knockout Cell Lines lies in their application in both research and clinical settings. They offer critical insights into the mechanistic underpinnings of diseases where HECTD4 is implicated, enabling the exploration of potential therapeutic strategies. Researchers can leverage these cell lines in drug discovery and validation studies or to elucidate the molecular consequences of HECTD4 disruption, making them an essential tool for translational research.

Unlike traditional models, these knockout cell lines provide a precise and reliable method for studying gene function without the confounding factors associated with leaky expression or residual protein activity. Furthermore, they are engineered for high efficiency, reducing the time and resources typically required to establish functional knockout models.

For researchers and clinicians invested in genetic studies and therapeutic development, HECTD4 Gene Knockout Cell Lines are an indispensable resource. They present a compelling opportunity to drive forward the understanding of essential biological processes and the development of innovative treatment options.

Our company is dedicated to advancing scientific research through the provision of high-quality biological products, backed by a team of experts in genetic engineering and cell biology, ensuring our offerings meet the needs of the scientific community and contribute to groundbreaking discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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