Gene: H3C8
Official Full Name: H3 clustered histone 8provided by HGNC
Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34232 | H3C8 Knockout cell line (HeLa) | Human | H3C8 | 1:3~1:6 | Negative | Online Inquiry |
H3C8 Gene Knockout Cell Lines consist of genetically modified cells where the H3C8 gene has been selectively disrupted through established gene-editing technologies such as CRISPR-Cas9. These cell lines serve as powerful tools in molecular biology and genetics, providing researchers with the ability to study gene function, signaling pathways, and the biological implications of genetic changes. By removing the H3C8 gene, these cell lines facilitate the investigation of its role in various cellular processes such as proliferation, differentiation, and response to external stimuli.
The fundamental mechanism of these knockout cell lines lies in the precise targeting and alteration of the H3C8 locus, which results in a complete lack of functional protein expression. Consequently, researchers can observe phenotypic changes and establish causative relationships between the absence of H3C8 and specific biological outcomes. This functionality makes H3C8 knockout cell lines invaluable for studies in cancer research, drug discovery, and therapeutic development.
H3C8 Gene Knockout Cell Lines are particularly significant in research and clinical settings where understanding the role of specific genes in health and disease is crucial. The insights gained from experiments using these cell lines can lead to identifying new therapeutic targets or biomarkers, thus accelerating innovation in biomedical research.
Compared to traditional methods such as RNA interference or chemical inhibitors, H3C8 gene knockout cell lines provide a more permanent solution to gene regulation, leading to reproducible results with higher specificity. This makes them an advantageous alternative for researchers seeking to explore long-term effects of gene loss in various experimental contexts.
For researchers and clinicians, the implementation of H3C8 Gene Knockout Cell Lines opens doors to unprecedented insights and advancements. Their reliability and capacity to enhance experimental precision make them a profound asset in the toolkit of modern biological research.
Our company specializes in the development and production of high-quality genetic models, ensuring that our products meet rigorous scientific standards and support groundbreaking research initiatives. With our expertise in gene editing, we are committed to advancing the scientific community's capabilities and facilitating discoveries that can lead to improved health outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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