Gene: H3-5
Official Full Name: H3.5 histoneprovided by HGNC
Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded by this gene is a replication-independent histone that is a member of the histone H3 family. [provided by RefSeq, Oct 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO17186 | H3-5 Knockout cell line (HCT 116) | Human | H3-5 | 1:2~1:4 | Negative | Online Inquiry |
KO17187 | H3-5 Knockout cell line (A549) | Human | H3-5 | 1:3~1:4 | Negative | Online Inquiry |
H3-5 Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate in-depth studies of gene function by providing a platform where the H3-5 gene has been systematically disrupted. Utilizing CRISPR-Cas9 technology, these cell lines allow researchers to create precise deletions or mutations within the genome, enabling the investigation of gene contributions to various biological processes and disease states.
The key function of H3-5 Gene Knockout Cell Lines lies in their ability to mimic genetic deletions that provide insights into the role of the H3-5 gene in cell signaling, differentiation, and pathological conditions. By studying these knockout models, scientists can elucidate the molecular mechanisms that underlie gene expression regulation and identify potential therapeutic targets. The precise manipulation of the gene allows for a more rigorous analysis of gene function compared to traditional genetic modification techniques, making it a valuable resource in functional genomics studies.
The scientific importance of these cell lines spans various fields, including cancer research, developmental biology, and neurobiology. Their application in clinical settings can lead to the discovery of novel biomolecular pathways pertinent to disease, thus accelerating drug development and precision medicine initiatives. Researchers can better understand the correlations between specific gene functions and cellular outcomes, enhancing the potential for targeted therapies.
Compared to alternative models, H3-5 Gene Knockout Cell Lines offer unique advantages, such as increased specificity in targeting the gene of interest and the ability to generate reproducible results. These cell lines save valuable research time and resources by allowing for the straightforward assessment of phenotypic outcomes linked to gene knockout without the confounding factors present in less precise models.
For researchers and clinicians seeking reliable, accurate tools to study gene function, H3-5 Gene Knockout Cell Lines represent a cutting-edge solution. The precision and reliability of these models underscore their importance in advancing scientific knowledge and clinical applications, making them an essential addition to any laboratory’s toolkit. Our company specializes in biotechnological innovations, standing at the forefront of producing high-quality gene models that empower the research community to unravel complex biological questions effectively.
Please note that all services are for research use only. Not intended for any clinical use.
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