Gene: H2BC17
Official Full Name: H2B clustered histone 17provided by HGNC
Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34250 | H2BC17 Knockout cell line (HeLa) | Human | H2BC17 | 1:3~1:6 | Negative | Online Inquiry |
KO34251 | H2BC17 Knockout cell line (HCT 116) | Human | H2BC17 | 1:2~1:4 | Negative | Online Inquiry |
KO34252 | H2BC17 Knockout cell line (HEK293) | Human | H2BC17 | 1:3~1:6 | Negative | Online Inquiry |
KO34253 | H2BC17 Knockout cell line (A549) | Human | H2BC17 | 1:3~1:4 | Negative | Online Inquiry |
H2BC17 Gene Knockout Cell Lines are a sophisticated tool utilized in molecular biology and genetic research to investigate gene function and regulation. These cell lines have been engineered through advanced CRISPR-Cas9 technology to precisely disrupt the H2BC17 gene, enabling researchers to study the resulting phenotypic changes and downstream molecular effects with high specificity. The knockout mechanism allows scientists to systematically observe the absence of gene expression and its impact on various cellular pathways, providing insights into cellular processes such as proliferation, differentiation, and apoptosis.
The H2BC17 gene is implicated in critical biological processes, making its knockout invaluable for understanding oncogenesis and other pathological conditions. In research and clinical settings, these cell lines serve as a foundation for drug screening, target validation, and the development of therapeutic strategies aimed at diseases linked to H2BC17 dysregulation. The availability of H2BC17 knockout models accelerates the pace of research by enabling precise gene manipulation, which can be crucial for disease modeling and functional genomics.
One distinctive advantage of H2BC17 Gene Knockout Cell Lines is their unparalleled specificity and reproducibility compared to traditional gene knockout methods, such as homologous recombination, which can introduce variability and off-target effects. The CRISPR-Cas9 approach ensures minimal disruption to the rest of the genome, providing more reliable data for downstream applications.
For researchers and clinicians, the ability to effectively study gene function through these knockout lines is critical in developing targeted therapies and understanding complex biological questions. Furthermore, our company prides itself on its commitment to integrating cutting-edge technologies with a deep understanding of biological processes, ensuring that our products meet the highest standards of scientific integrity and utility. By continually supporting the evolving needs of researchers and clinicians, we advance scientific discovery and potential therapeutic advancements.
Please note that all services are for research use only. Not intended for any clinical use.
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