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H1-2 Knockout Cell Lines

Gene: H1-2

Official Full Name: H1.2 linker histone, cluster memberprovided by HGNC

Gene Summary: Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37439 H1-2 Knockout cell line (HeLa) Human H1-2 1:3~1:6 Negative Online Inquiry
KO37440 H1-2 Knockout cell line (HCT 116) Human H1-2 1:2~1:4 Negative Online Inquiry
KO37441 H1-2 Knockout cell line (HEK293) Human H1-2 1:3~1:6 Negative Online Inquiry
KO37442 H1-2 Knockout cell line (A549) Human H1-2 1:3~1:4 Negative Online Inquiry

Background

H1-2 Gene Knockout Cell Lines are genetically engineered cells where the H1-2 gene has been selectively disrupted, allowing researchers to study the gene's role in cellular processes under controlled conditions. These knockout models are invaluable tools in molecular biology, enabling scientists to investigate gene function, signaling pathways, and the impact of specific genetic alterations on cellular behavior. The mechanism of action involves the use of CRISPR-Cas9 technology or other genome-editing techniques, which introduce targeted mutations to produce functional deletions in the H1-2 gene.

The scientific importance of H1-2 Gene Knockout Cell Lines lies in their application in various research domains, including cancer biology, neurobiology, and pharmacogenomics. By utilizing these models, researchers can elucidate the pathogenic mechanisms associated with H1-2 gene expression, assess potential therapeutic targets, and evaluate the efficacy of novel drug candidates. Their utility extends to translational studies where understanding the genetic architecture of diseases can lead to targeted therapies in clinical settings.

Compared to other gene-editing alternatives such as RNA interference, H1-2 knockout models provide a stable and permanent alteration of the gene, thereby allowing for long-term studies of gene function and associated phenotypic effects. Additionally, the specificity of knockout approaches minimizes off-target effects further ensuring the integrity of experimental results.

By adopting H1-2 Gene Knockout Cell Lines, researchers and clinicians gain access to a powerful tool for dissecting molecular mechanisms and advancing precision medicine initiatives. Backed by extensive expertise in genetic engineering and cell line development, our company is committed to providing high-quality, validated knockout models that enhance research efficiency and reliability. This product epitomizes our dedication to empowering scientific discovery through innovative biological solutions.

Please note that all services are for research use only. Not intended for any clinical use.

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