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GYG1 Knockout Cell Lines

Gene: GYG1

Official Full Name: glycogenin 1provided by HGNC

Gene Summary: This gene encodes a member of the glycogenin family. Glycogenin is a glycosyltransferase that catalyzes the formation of a short glucose polymer from uridine diphosphate glucose in an autoglucosylation reaction. This reaction is followed by elongation and branching of the polymer, catalyzed by glycogen synthase and branching enzyme, to form glycogen. This gene is expressed in muscle and other tissues. Mutations in this gene result in glycogen storage disease XV. This gene has pseudogenes on chromosomes 1, 8 and 13 respectively. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37452 GYG1 Knockout cell line (HeLa) Human GYG1 1:3~1:6 Negative Online Inquiry
KO37453 GYG1 Knockout cell line (HCT 116) Human GYG1 1:2~1:4 Negative Online Inquiry
KO37454 GYG1 Knockout cell line (HEK293) Human GYG1 1:3~1:6 Negative Online Inquiry
KO37455 GYG1 Knockout cell line (A549) Human GYG1 1:3~1:4 Negative Online Inquiry

Background

GYG1 Gene Knockout Cell Lines are genetically engineered cell lines designed to enable comprehensive studies of GYG1 (glycogenin-1) gene function in various biological contexts. These cell lines are created using advanced genomic editing techniques such as CRISPR/Cas9, resulting in targeted disruptions of the GYG1 gene. This knockout approach allows researchers to investigate the physiological roles, regulatory mechanisms, and potential contributions of GYG1 to cellular metabolism and disease processes.

The primary function of these cell lines is to facilitate the understanding of GYG1’s involvement in glycogen biosynthesis and its impact on muscle and liver physiology. By creating a specific knockout, researchers can observe resultant phenotypic changes, providing insights into how GYG1 influences metabolism, energy homeostasis, and its potential links to metabolic disorders. Through experimentation, mechanisms that govern glycogen storage and utilization can be decoded, paving the way for breakthroughs in combating diseases such as diabetes and obesity.

The scientific significance of GYG1 Gene Knockout Cell Lines lies in their utility for both basic research and clinical applications. They serve as powerful tools for drug discovery, metabolic pathway analysis, and disease modeling, making them invaluable in the fields of biochemistry, pharmacology, and molecular biology. Moreover, these cell lines can facilitate high-throughput screening, greatly accelerating the identification of novel therapeutic targets.

What sets our GYG1 Gene Knockout Cell Lines apart from alternatives is the precision and efficiency of the knockout process, coupled with a comprehensive validation protocol that guarantees the integrity of the cell lines for experimental robustness. Each cell line undergoes rigorous testing to confirm the absence of GYG1 expression, ensuring that users obtain consistent and reproducible results.

Researchers and clinicians will find great value in our product’s ability to streamline experimental design and reduce time spent on validation, ultimately enhancing research productivity. Our in-depth knowledge in genetic engineering and commitment to providing high-quality biological products underscores our dedication to facilitating advancements in science and medicine. With GYG1 Gene Knockout Cell Lines, you gain a critical tool that can redefine our understanding of metabolic regulation and its implications for health.

Please note that all services are for research use only. Not intended for any clinical use.

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