Gene: GPR143
Official Full Name: G protein-coupled receptor 143provided by HGNC
Gene Summary: This gene encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. This protein is thought to be involved in intracellular signal transduction mechanisms. Mutations in this gene cause ocular albinism type 1, also referred to as Nettleship-Falls type ocular albinism, a severe visual disorder. A related pseudogene has been identified on chromosome Y. [provided by RefSeq, Dec 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36287 | GPR143 Knockout cell line (HCT 116) | Human | GPR143 | 1:2~1:4 | Negative | Online Inquiry |
GPR143 Gene Knockout Cell Lines are genetically engineered cellular models that facilitate the study of the GPR143 gene, which encodes the G protein-coupled receptor known for its role in regulating various physiological processes including pigment production, neuronal signaling, and developmental pathways. By creating knockout variants of this gene, researchers can analyze the effects of its absence on cellular functions, signaling pathways, and disease mechanisms, making these cell lines invaluable for both basic research and therapeutic investigations.
The primary function of GPR143 gene knockout cell lines is to enable the specific examination of the receptor’s role in cellular signaling and its impact on phenotypic outcomes. This is achieved through the precise deletion of the GPR143 gene, allowing scientists to observe alterations in physiological responses, investigate downstream signaling pathways, and model conditions that may lead to degenerative diseases, such as ocular or neurodegenerative disorders.
The scientific importance of these cell lines is underscored by their application in both research and clinical settings. They serve as a crucial tool for investigators studying the pathophysiology of disorders associated with GPR143 dysregulation and provide a platform for drug discovery and testing potential therapeutic compounds that target this receptor. Additionally, these knockout models can enhance the understanding of gene function and interplay in complex biological systems, contributing to more foundational insights in genomics and molecular biology.
Compared to existing alternatives, GPR143 Gene Knockout Cell Lines are designed for high specificity and reliability in genetic manipulation, ensuring reproducibility and robustness in experimental outcomes. Their use minimizes background variability which often complicates studies using standard cell lines.
For researchers and clinicians focused on unraveling the complexities of the GPR143 gene, these cell lines represent a pivotal resource, as they facilitate detailed exploration of gene functionality and pathology. This can directly contribute to the development of innovative approaches for diagnosing and treating related diseases.
Our company prides itself on its expertise in producing high-quality genetic models, ensuring that our GPR143 Gene Knockout Cell Lines are meticulously validated for enhanced research utility. With a commitment to supporting scientific advancement through reliable biological tools, we empower researchers to push the boundaries of discovery in health and disease.
Please note that all services are for research use only. Not intended for any clinical use.
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