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GPLD1 Knockout Cell Lines

Gene: GPLD1

Official Full Name: glycosylphosphatidylinositol specific phospholipase D1provided by HGNC

Gene Summary: Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37545 GPLD1 Knockout cell line (HCT 116) Human GPLD1 1:2~1:4 Negative Online Inquiry
KO37546 GPLD1 Knockout cell line (HEK293) Human GPLD1 1:3~1:6 Negative Online Inquiry
KO37547 GPLD1 Knockout cell line (A549) Human GPLD1 1:3~1:4 Negative Online Inquiry

Background

GPLD1 Gene Knockout Cell Lines are genetically engineered cell lines in which the GPLD1 gene has been selectively disrupted, resulting in the loss of its protein product, glycosylphosphatidylinositol-specific phospholipase D1. This innovative tool serves as a crucial model for studying the regulatory roles of GPLD1 in various biological processes, including tumorigenesis and immune response. By elucidating the physiological and pathological functions of this gene, researchers can gain deeper insights into disease mechanisms.

The key functions of GPLD1 involve the modulation of lipid signaling pathways and the release of membrane-bound proteins, contributing to processes such as cell adhesion, migration, and immune modulation. By using GPLD1 knockout cell lines, scientists can effectively assess the impact of GPLD1 deficiency on cellular behavior and signaling cascades. For instance, experiments can reveal how the absence of GPLD1 influences tumor cell proliferation or macrophage activation, thus aiding in the development of targeted therapies.

The scientific significance of GPLD1 knockout cell lines lies in their wide applicability in basic and translational research. They are invaluable in deciphering complex cellular interactions and validation of therapeutic strategies for various diseases, including cancer and autoimmune disorders.

Compared to traditional cell lines, these knockout models offer a distinct advantage by eliminating the confounding effects of GPLD1, thereby allowing for more accurate interpretations of experimental outcomes. They provide a robust system for drug screening, genetic studies, and functional assays, making them a superior choice for researchers focusing on cell signaling and pathophysiology.

For researchers and clinicians, investing in GPLD1 Gene Knockout Cell Lines translates to an enhanced ability to uncover novel therapeutic targets and biomarkers. With the potential to drive breakthroughs in treatment strategies, these cell lines are poised to play a pivotal role in advancing biomedical research.

At [Your Company Name], we specialize in providing high-quality biological products tailored to meet the needs of the scientific community. Our commitment to excellence ensures that our GPLD1 Gene Knockout Cell Lines are rigorously validated and ready to support your critical research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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