Gene: GPI
Official Full Name: glucose-6-phosphate isomeraseprovided by HGNC
Gene Summary: This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37551 | GPI Knockout cell line (HeLa) | Human | GPI | 1:3~1:6 | Negative | Online Inquiry |
KO37552 | GPI Knockout cell line (HCT 116) | Human | GPI | 1:2~1:4 | Negative | Online Inquiry |
KO37553 | GPI Knockout cell line (HEK293) | Human | GPI | 1:3~1:6 | Negative | Online Inquiry |
KO37554 | GPI Knockout cell line (A549) | Human | GPI | 1:3~1:4 | Negative | Online Inquiry |
GPI Gene Knockout Cell Lines are advanced biological tools designed to facilitate the study of glycerol-3-phosphate acyltransferase (GPI), a crucial enzyme involved in lipid metabolism and cellular signaling pathways. By employing cutting-edge CRISPR/Cas9 technology, these cell lines enable researchers to specifically disable the GPI gene, creating an environment that simulates GPI-related deficiencies. This knockout approach provides unparalleled insights into the functional role of GPI within various biological contexts, ranging from metabolic regulation to disease progression.
The key mechanism of action involves the targeted disruption of GPI gene sequences, allowing researchers to observe the resultant phenotypic changes and cellular behaviors. This can elucidate the intricate role of GPI in cellular homeostasis, impacting areas such as energy metabolism and cellular responses to stress. The resulting cell lines serve as an invaluable platform for studying the implications of GPI deficiency in metabolic disorders, cancer, and neurodegenerative diseases, among others.
Scientifically, GPI Gene Knockout Cell Lines are pivotal in translational research, providing the potential for the development of novel therapeutic strategies. Compared to traditional gene-editing techniques, the CRISPR-based approach offers improved efficiency, specificity, and reproducibility, resulting in reliable and precise models that enhance the accuracy of experimental results.
Researchers and clinicians can significantly benefit from the unique advantages offered by our GPI Gene Knockout Cell Lines, including the potential for high-throughput screening and drug discovery applications. The ability to analyze the effects of pharmacological agents or genetic manipulations on GPI-deficient models not only accelerates research timelines but also enhances the translational value of findings to clinical practice.
At our company, we pride ourselves on our expertise in developing high-quality biological products that empower scientific discovery. Our commitment to innovation ensures that researchers receive the best tools available for exploring the complexities of biological systems, allowing for enhanced understanding and tackling of pressing health challenges.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.