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GPAT2 Knockout Cell Lines

Gene: GPAT2

Official Full Name: glycerol-3-phosphate acyltransferase 2, mitochondrialprovided by HGNC

Gene Summary: Enables glycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in glycerol-3-phosphate metabolic process; glycerolipid biosynthetic process; and piRNA processing. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22029 GPAT2 Knockout cell line (HeLa) Human GPAT2 1:3~1:6 Negative Online Inquiry
KO22030 GPAT2 Knockout cell line (HCT 116) Human GPAT2 1:2~1:4 Negative Online Inquiry

Background

GPAT2 Gene Knockout Cell Lines are specialized cellular models engineered to lack the GPAT2 gene, which is critical for glycerolipid metabolism and fatty acid synthesis. These cell lines serve as vital tools in investigating the biological roles of GPAT2 in various physiological and pathological contexts, including metabolic disorders, cancer progression, and therapeutic response.

The primary function of GPAT2 is to catalyze the first committed step in glycerolipid biosynthesis, significantly influencing the intracellular lipid composition and energy homeostasis. In these knockout cell lines, researchers can elucidate the mechanisms underlying GPAT2's involvement in cellular processes such as lipid droplet formation, membrane integrity, and cell signaling pathways that pertain to lipid metabolism. By comparing GPAT2-deficient cells to wild-type counterparts, scientists can assess the gene's contributions to metabolic pathways and its implication in disease states.

The scientific importance of GPAT2 Gene Knockout Cell Lines is underscored by their applications in both research and clinical settings. They can be employed in drug discovery platforms to evaluate the effects of novel compounds on lipid metabolism and in studying metabolic diseases such as obesity and diabetes. Moreover, these cell lines facilitate basic research aimed at understanding cancer biology, particularly how altered lipid metabolism can influence tumor growth and metastasis.

What sets GPAT2 Gene Knockout Cell Lines apart from alternative models is their specificity and precision. They allow for controlled, reproducible experimental conditions that enable researchers to focus directly on the role of the GPAT2 gene without the confounding effects present in non-specific approaches. This specificity not only enhances the reliability of experimental outcomes but also accelerates the path from bench to bedside by identifying actionable therapeutic targets and biomarkers.

For researchers, clinicians, and pharmaceutical companies, the value of employing GPAT2 Gene Knockout Cell Lines lies in their ability to drive significant discoveries in lipid biology and disease mechanisms. They represent an essential resource for innovative research, delivering insights that could lead to the development of next-generation therapeutics.

Our company, with a strong background in genetic engineering and cell line development, is dedicated to providing high-quality biological products that empower researchers worldwide. We leverage our expertise to ensure that our GPAT2 Gene Knockout Cell Lines are optimized for maximum performance in a variety of experimental settings.

Please note that all services are for research use only. Not intended for any clinical use.

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