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GNAL Knockout Cell Lines

Gene: GNAL

Official Full Name: G protein subunit alpha Lprovided by HGNC

Gene Summary: This gene encodes a stimulatory G protein alpha subunit which mediates odorant signaling in the olfactory epithelium. This protein couples dopamine type 1 receptors and adenosine A2A receptors and is widely expressed in the central nervous system. Mutations in this gene have been associated with dystonia 25 and this gene is located in a susceptibility region for bipolar disorder and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08130 GNAL Knockout cell line (HeLa) Human GNAL 1:3~1:6 Negative Online Inquiry
KO08131 GNAL Knockout cell line (HCT 116) Human GNAL 1:2~1:4 Negative Online Inquiry
KO08132 GNAL Knockout cell line (HEK293) Human GNAL 1:3~1:6 Negative Online Inquiry
KO08133 GNAL Knockout cell line (A549) Human GNAL 1:3~1:4 Negative Online Inquiry

Background

GNAL Gene Knockout Cell Lines represent an advanced cell line model engineered for the specific ablation of the guanine nucleotide-binding protein, GNAL. These cell lines have been meticulously developed using CRISPR/Cas9 technology to provide a precise, efficient means of studying the biological roles of GNAL in various physiological and pathological contexts. The knockout of GNAL facilitates in-depth exploration of its involvement in signaling pathways, particularly those related to neurotransmitter systems and cardiovascular functions.

Functionally, GNAL Gene Knockout Cell Lines offer researchers a powerful mechanism to dissect the impacts of GNAL deficiency on cell signaling and phenotype. By eliminating GNAL expression, investigators can observe resultant changes in cyclic nucleotide levels, cell proliferation, and differentiation, allowing for the elucidation of GNAL's role in diseases such as Parkinson’s and other neurodegenerative conditions. These cell lines are invaluable in experimental settings that aim to investigate gene function, perform drug screening, or develop targeted therapies.

The scientific importance of GNAL Gene Knockout Cell Lines lies in their ability to contribute to a deeper understanding of GNAL's involvement in human health and disease, thus enabling advancements in therapeutic strategies. Compared to other gene knockout models, the precision of CRISPR technology in these cell lines significantly reduces off-target effects, ensuring the fidelity of experimental outcomes.

For researchers and clinicians, the acquisition of GNAL Gene Knockout Cell Lines enhances experimental rigor and expands the toolkit for genetic research. Their bespoke nature aligns seamlessly with current trends in personalized medicine and genetic therapy, making them a preferred choice over conventional models.

At our company, we pride ourselves on our commitment to innovation and quality in biological products. With a robust portfolio of advanced cell line models and a dedicated team of experts, we empower researchers to push the boundaries of science and develop novel solutions for pressing health challenges.

Please note that all services are for research use only. Not intended for any clinical use.

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