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GNAI3 Knockout Cell Lines

Gene: GNAI3

Official Full Name: G protein subunit alpha i3provided by HGNC

Gene Summary: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. [provided by RefSeq, Jun 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08750 GNAI3 Knockout cell line (HeLa) Human GNAI3 1:3~1:6 Negative Online Inquiry
KO08751 GNAI3 Knockout cell line (HCT 116) Human GNAI3 1:2~1:4 Negative Online Inquiry
KO08752 GNAI3 Knockout cell line (HEK293) Human GNAI3 1:3~1:6 Negative Online Inquiry
KO08753 GNAI3 Knockout cell line (A549) Human GNAI3 1:3~1:4 Negative Online Inquiry

Background

GNAI3 Gene Knockout Cell Lines are genetically engineered cell lines in which the GNAI3 gene, crucial for various signaling pathways, has been precisely disrupted. This knockout strategy allows researchers to elucidate the specific role of GNAI3 in cellular processes such as signal transduction, cell proliferation, and differentiation, which are often implicated in diseases like cancer and metabolic disorders.

The primary function of GNAI3 is to encode a protein that acts as an intracellular signaling molecule, part of the G protein family. By facilitating the communication between cell surface receptors and downstream effector enzymes, GNAI3 plays an integral role in mediating various physiological responses. Upon the knockout of this gene, researchers can observe resultant changes in cellular behavior, helping to dissect the functional pathways involving GNAI3, including those associated with G protein-coupled receptor (GPCR) signaling.

From a scientific standpoint, GNAI3 Gene Knockout Cell Lines are invaluable tools for research in pharmacology, molecular biology, and therapeutic development. These cell lines enable the study of gene function in a controlled environment, providing insights into the pathogenesis of GNAI3-associated disorders. Additionally, they can serve as models for drug screening and the assessment of therapeutic candidates targeting the GNAI3 signaling pathway.

Compared to traditional methods of gene inhibition, such as siRNA or chemical inhibitors, GNAI3 gene knockout offers a more permanent and specific alteration, allowing for more reliable results and reproducibility in experiments. This permanence reduces the experimental variability often seen with transient approaches and provides a clearer picture of the role of GNAI3 in various biological contexts.

For researchers and clinicians focusing on signal transduction pathways, the GNAI3 Gene Knockout Cell Lines represent an essential resource that enhances understanding of complex biological systems, bridging fundamental research to potential clinical applications. Our company leverages years of expertise in genetic engineering and cell line development to provide high-quality, validated products that meet the urgent needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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