Gene: GNAI1
Official Full Name: G protein subunit alpha i1provided by HGNC
Gene Summary: Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. The protein encoded by this gene represents the alpha subunit of an inhibitory complex. The encoded protein is part of a complex that responds to beta-adrenergic signals by inhibiting adenylate cyclase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08754 | GNAI1 Knockout cell line (HeLa) | Human | GNAI1 | 1:3~1:6 | Negative | Online Inquiry |
KO08755 | GNAI1 Knockout cell line (HCT 116) | Human | GNAI1 | 1:2~1:4 | Negative | Online Inquiry |
KO08756 | GNAI1 Knockout cell line (HEK293) | Human | GNAI1 | 1:3~1:6 | Negative | Online Inquiry |
KO08757 | GNAI1 Knockout cell line (A549) | Human | GNAI1 | 1:3~1:4 | Negative | Online Inquiry |
GNAI1 Gene Knockout Cell Lines are engineered cellular models specifically designed to investigate the functional role of the GNAI1 gene, which encodes the alpha subunit of a family of guanine nucleotide-binding proteins (G proteins). These cell lines have undergone homologous recombination or CRISPR-Cas9 gene editing to create a precise deletion of the GNAI1 gene, effectively enabling researchers to study the biological consequences of its absence.
The primary function of GNAI1 proteins is to modulate intracellular signaling pathways that regulate various cellular processes such as proliferation, differentiation, and metabolism. By utilizing these knockout cell lines, scientists can dissect the signaling dynamics that are altered in the absence of GNAI1, thus providing critical insights into its role in diseases such as cancer, metabolic disorders, and neurological conditions. The utilization of these cell lines assists in elucidating the mechanistic pathways that can be targeted for therapeutic development.
One of the significant scientific advantages of GNAI1 Gene Knockout Cell Lines is their specificity; they allow for the observation of changes in cellular behavior without the confounding effects of gene expression variability present in heterozygous or wild-type cells. This specificity empowers researchers by providing robust experimental models that improve the reliability of data, aiding in the translation of findings to clinical settings. Compared to traditional knockout models, these engineered cell lines offer enhanced efficiency in maintaining stable gene disruptions over generations.
The value of GNAI1 Gene Knockout Cell Lines is particularly pronounced for researchers and clinicians aiming to identify new biomarkers or drug targets aligned with GNAI1 signaling pathways. As precision medicine approaches gain traction, the insights gained from these models can lead to the development of targeted therapies that improve patient outcomes.
Our company prides itself on being at the forefront of genetic engineering and cell line development, delivering high-quality biological products that empower scientific research and discovery. With expertise in advanced editing technologies, we offer not only GNAI1 Gene Knockout Cell Lines but also a range of tailored solutions to meet the evolving needs of researchers in the life sciences domain.
Please note that all services are for research use only. Not intended for any clinical use.
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