Gene: GLIS2
Official Full Name: GLIS family zinc finger 2provided by HGNC
Gene Summary: This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear transcription factor with five C2H2-type zinc finger domains. The protein encoded by this gene is widely expressed at low levels in the neural tube and peripheral nervous system and likely promotes neuronal differentiation. It is abundantly expressed in the kidney and may have a role in the regulation of kidney morphogenesis. p120 regulates the expression level of this protein and induces the cleavage of this protein's C-terminal zinc finger domain. This protein also promotes the nuclear translocation of p120. Mutations in this gene cause nephronophthisis (NPHP), an autosomal recessive kidney disease characterized by tubular basement membrane disruption, interstitial lymphohistiocytic cell infiltration, and development of cysts at the corticomedullary border of the kidneys.[provided by RefSeq, Jan 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO24743 | GLIS2 Knockout cell line (HeLa) | Human | GLIS2 | 1:3~1:6 | Negative | Online Inquiry |
KO24744 | GLIS2 Knockout cell line (HCT 116) | Human | GLIS2 | 1:2~1:4 | Negative | Online Inquiry |
KO24745 | GLIS2 Knockout cell line (A549) | Human | GLIS2 | 1:3~1:4 | Negative | Online Inquiry |
GLIS2 Gene Knockout Cell Lines are advanced biological tools designed to study the function of the GLIS2 gene, known for its role in various cellular processes, including regulation of cell differentiation, proliferation, and metabolism. These engineered cell lines have been meticulously developed using CRISPR/Cas9 technology to create precise knockouts of the GLIS2 gene, allowing researchers to observe the resulting phenotypic changes and infer the gene’s biological significance.
The key function of GLIS2 Gene Knockout Cell Lines lies in their ability to facilitate investigations into the molecular pathways associated with GLIS2. By removing the expression of this gene, researchers can explore its impact on cellular mechanisms such as epithelial-mesenchymal transition, stem cell function, and the metabolic adaptations of cells under different environmental conditions. This knockout model serves as a powerful platform for identifying potential therapeutic targets and understanding the pathology of diseases linked to GLIS2 dysfunction.
The scientific importance of these cell lines extends to various research fields, including developmental biology, cancer research, and regenerative medicine. In clinical settings, the data gathered from studies utilizing GLIS2 knockouts can inform the development of gene therapies and novel treatment strategies for diseases where GLIS2 is implicated.
Compared to alternative products, our GLIS2 Gene Knockout Cell Lines offer superior specificity and reliability, ensuring that the observed effects are directly attributable to the loss of GLIS2 function. This is a significant advantage over traditional approaches that may not fully account for off-target effects. Additionally, our lines are ready-to-use, which streamlines the research process and reduces time spent on preliminary preparations.
For researchers and clinicians alike, the value of GLIS2 Gene Knockout Cell Lines lies in their ability to catalyze discoveries that can lead to breakthroughs in understanding gene function and disease mechanisms. Our commitment to high-quality products and ongoing support reflects our dedication to advancing scientific research.
With a robust background in genetic engineering and a solid reputation in developing cutting-edge biological tools, our company is ideally positioned to support researchers in their quest for knowledge and innovation in the life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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